Tamoxifen citrate induced sperm shape abnormalities in the in vivo mouse

被引：0
|
作者：
Rai, SP [1 ]
Vijayalaxmi, KK
机构：
[1] Kuvempu Univ, Dept Biotechnol, Shimoga 577451, India
[2] Mangalore Univ, Dept Appl Zool, Mangalagangothri 574119, DK, India
来源：
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2001年 / 492卷 / 1-2期
关键词：
tamoxifen citrate; Swiss albino mice; sperm abnormality; sperm count;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The genotoxic potential of an anticancer drug, tamoxifen citrate, was studied in the in vivo mouse system using the sperm abnormality assay. Sperms of Swiss albino mice were examined after 5 weeks of repeated administration of different doses of the drug for 10 days. The doses used were 0.1, 0.2, 0.4 and 0.8 mg/kg b.w. per day. Statistically significant sperm abnormalities revealed the genotoxic potency of this drug. (C) 2001 Elsevier Science B.V. All rights reserved.
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页码：1 / 6
页数：6
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