Deregulated expression of the TAL1 gene by t(1;5)(p32;q31) in patient with T-Cell acute lymphoblastic leukemia

TALI gene deregulation is frequent in T-cell acute lymphoblastic leukemia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome I. This study presents a case of T-ALL with a t(1;5)(p32;q31) involving TAL I, in which the breakpoint occurs approximately 10 kbp 5' to the gene and leads to transcriptional activation and synthesis of a TALI protein, and extends the spectrum of recognized TALI gene translocations associated with T-ALL. (C) 1998 Wiley-Liss, Inc.