Treatment with dihydroethidium reduces infarct size after transient focal cerebral ischemia in mice

被引：12
|
作者：
Yu, FS
Sugawara, T
Chan, PH
机构：
[1] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Dept Neurosurg, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Neurosci Program, Stanford, CA 94305 USA
来源：
BRAIN RESEARCH | 2003年 / 978卷 / 1-2期
关键词：
delayed treatment; dihydroethidium; focal cerebral ischemia; neuroprotection; stroke; superoxide anion;
D O I：
10.1016/S0006-8993(03)02775-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A transient focal ischemia model with C57B1/6 mice was used to investigate whether dihydroethidium is neuroprotective. Different doses (25, 50, 100 mg/kg body weight) were used for pretreatment and the lowest effective dose was used for delayed treatment 1 and 2 h after reperfusion. Our results demonstrate that all the doses used for treatment reduced infarct volume. We conclude that dihydroethidium is neuroprotective by reducing superoxide in mice after stroke. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：223 / 227
页数：5
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