Fluorescent vinblastine probes for live cell imaging

被引：11
|
作者：
Meimetis, Labros G. [1 ]
Giedt, Randy J. [1 ]
Mikula, Hannes [1 ]
Carlson, Jonathan C. [1 ]
Kohler, Rainer H. [1 ]
Pirovich, David B. [1 ]
Weissleder, Ralph [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Ctr Syst Biol, 185 Cambridge St,CPZN 5206, Boston, MA 02114 USA
[2] Harvard Med Sch, Dept Syst Biol, 200 Longwood Ave, Boston, MA 02115 USA
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 64期
基金：
美国国家卫生研究院;
关键词：
DIMERIC CATHARANTHUS ALKALOIDS; TUBULIN; MICROTUBULES; VINCRISTINE; AGENTS;
D O I：
10.1039/c6cc04129a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein we describe the synthesis of several fluorescent analogues of the clinically approved microtubule destabilizing agent vinblastine. The evaluated probes are the most potent described and provides the first example of uptake, distribution and live cell imaging using this well known antimitotic agent.
引用
收藏
页码：9953 / 9956
页数：4
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