Absence of the HIV-1 protective Δccr5 allele in most ethnic populations of India

被引：22

作者：

Majumder, PP ^{[1
]}

Dey, B ^{[1
]}

机构：

[1] Indian Stat Inst, Anthropol & Human Genet Unit, Kolkata 700035, W Bengal, India

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2001年 / 9卷 / 10期

关键词：

tribe; caste; HIV resistance;

D O I：

10.1038/sj.ejhg.5200705

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent epidemiological data and projections indicate that HIV infection will spread rapidly in India. An allele Delta ccr5 of the beta -chemokine receptor gene CCR5 has been found to confer protection against HIV-1. We find that this protective allele is absent in most ethnic populations of India, except some populations of the northern and western regions where this allele may have been introduced by Caucasian gene flow. The implications of this finding are discussed in the light of increasing HIV prevalence in India.

引用

页码：794 / 796

页数：3

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