Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese

To investigate the possible involvement of the transferrin (TF) gene polymorphism in the manifestation of Alzheimer's disease (AD), we analyzed the TF and apolipoprotein E (APOE) genotypes of 67 sporadic late-onset AD patients and 131 normal elderly controls in the Chinese population. Our data showed that the TF C1 homozygosity carriers had an increased risk of AD in subjects greater than or equal to75 years of age, showing that homozygosity for the TF C1 allele was associated with an approximately three-fold increased risk (OR = 3.57, 95% C1, 1.24-10.27, P = 0.014). No synergic effects were found between the APOE epsilon4 allele and TF gene polymorphisms. (C) 2003 Elsevier Ireland Ltd. All rights reserved.