Evaluation of the Bio-Rad VARIANT™ II HbA2/HbA1C Dual Program for measurement of hemoglobin concentrations and detection of variants

被引：8
|
作者：
Riou, J
Godart, C
Mathis, M
Hurtrel, D
Wajcman, H
Préhu, C
Bardakdjian, J
机构：
[1] Hop Henri Mondor, Serv Biochem Genet, F-94010 Creteil, France
[2] Hop Henri Mondor, INSERM, U468, F-94010 Creteil, France
来源：
CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2005年 / 43卷 / 02期
关键词：
hemoglobin A(2); hemoglobin F; sickle cell disease; thalassemia;
D O I：
10.1515/CCLM.2005.040
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
In this work data obtained on the VARIANT(TM) II hemoglobin analyzer using the Dual Kit elution system were compared to those obtained with the beta-Thalassemia Short Program. Since many laboratories still use an earlier model of the hemoglobin analyzer, the Variant(TM) 1, these data were also compared to those obtained with the latter instrument. Our study is divided into two parts. The first is an evaluation of the precision of the VARIANT(TM) II for determining the levels of hemoglobin (Hb)A(2) and Hb F. This was carried out for normal subjects, thalassemic patients and patients with HbS. The second part concerns the potential of this instrument in the presumptive identification of Hb variants.
引用
收藏
页码：237 / 243
页数：7
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