Preparation, toxicity reduction and radiation therapy application of gold nanorods

被引：13
|
作者：
Xie, Lina [1 ]
Zhang, Xujia [2 ]
Chu, Chengchao [3 ]
Dong, Yingqi [2 ]
Zhang, Tianzi [2 ]
Li, Xinyue [1 ]
Liu, Gang [4 ,5 ]
Cai, Wen [2 ]
Han, Suxia [1 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Radiat Oncol, Xian 710061, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Basic Med Sci, Inst Med Engn, Xian 710061, Shaanxi, Peoples R China
[3] Xiamen Univ, Eye Inst, Sch Med, Fujian Prov Key Lab Ophthalmol & Visual Sci, Xiamen 361102, Fujian, Peoples R China
[4] Xiamen Univ, State Key Lab Mol Vaccinol, Sch Publ Hlth, Xiamen 361102, Fujian, Peoples R China
[5] Xiamen Univ, Mol Diagnost Ctr Mol Imaging & Translat Med, Sch Publ Hlth, Xiamen 361102, Fujian, Peoples R China
来源：
JOURNAL OF NANOBIOTECHNOLOGY | 2021年 / 19卷 / 01期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Gold nanorods (GNRs); Preparation; Toxicity reduction; Radiation sensitization; Radiation therapy; SEED-MEDIATED GROWTH; CORE-SHELL GOLD; PHOTOTHERMAL THERAPY; PHOTOCHEMICAL-SYNTHESIS; BREAST-CANCER; NANOPARTICLES; RADIOSENSITIZATION; RADIOTHERAPY; SHAPE; NANOSTRUCTURES;
D O I：
10.1186/s12951-021-01209-4
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Gold nanorods (GNRs) have a broad application prospect in biomedical fields because of their unique properties and controllable surface modification. The element aurum (Au) with high atomic number (high-Z) render GNRs ideal radiosensitive materials for radiation therapy and computed tomography (CT) imaging. Besides, GNRs have the capability of efficiently converting light energy to heat in the near-infrared (NIR) region for photothermal therapy. Although there are more and more researches on GNRs for radiation therapy, how to improve their biocompatibility and how to efficiently utilize them for radiation therapy should be further studied. This review will focuse on the research progress regarding the preparation and toxicity reduction of GNRs, as well as GNRs-mediated radiation therapy.
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页数：17
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