Metal-Free Synthesis of Methylene-Bridged Bisamide via Selectfluor-Mediated Oxidative Methylenation

被引：16
|
作者：
Yan, Min [1 ]
Zhou, Dongheng [1 ,2 ]
Gao, Yejun [1 ]
Ma, Yongmin [1 ]
机构：
[1] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China
[2] Zhejiang Univ, Dept Biochem & Mol Biol, Hangzhou 310058, Zhejiang, Peoples R China
来源：
CHEMISTRYSELECT | 2018年 / 3卷 / 46期
关键词：
Amides; DMSO; methylenebisamides; methylenation; Selectfluor; C-N CLEAVAGE; BIS-1,3-DICARBONYL COMPOUNDS; GOLD; DMSO; DISCOVERY; ACCESS; AMINES; BONDS;
D O I：
10.1002/slct.201802450
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A direct methylenation of amides to afford methylene-bridged bisamides mediated by Selectfluor in the presence of dimethyl sulfoxide (DMSO) was achieved. DMSO plays a dual role in this reaction, as both solvent and a methylene source. The developed protocol avoids the use of transition metal catalysts and the reaction is efficient, operationally convenient and tolerable in air and water.
引用
收藏
页码：13006 / 13009
页数：4
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