Mechanisms of Platelet-Leucocyte Interactions in the Norm and Cardiovascular Pathology

Interactions between blood cells in the form of cell aggregates occurs in various cardiovascular diseases. Prerequisite for formation of platelet leukocyte aggregates (PLA) is activation of at least one type of cells caused by a wide range of regulators. Platelets, because of the expression of specific adhesion molecules, Toll-like receptors, secretion of chemokines, cytokines and arachidonic acid metabolites are able to interact with neutrophils, monocytes and lymphocytes. This determines relationship between processes of thrombogenesis and inflammation as well as the role of platelets in realization of specific and nonspecific immunity and envisages stereotypical reaction of peripheral blood with formation of PLA. Investigation of the specificity and mechanisms of platelet-leukocyte interactions in various diseases will allow to use analysis of PLA for prediction of outcomes of the pathological processes and assess effectiveness of therapy.