Inhibition of JNK by HGF/SF prevents apoptosis induced by TNF-α

被引：5

作者：

Reveneau, S

Paumelle, R

Deheuninck, J

Leroy, C

De Launoit, Y

Fafeur, V

机构：

[1] EPHE, INSERM, U517, F-21079 Dijon, France

[2] Inst Pasteur, CNRS, Unite Mixte Rech 8117, Inst Biol Lille, F-59021 Lille, France

来源：

APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS | 2003年 / 1010卷

关键词：

hepatocyte growth factor; scatter factor; JNK; tumor necrosis factor-alpha;

D O I：

10.1196/annals.1299.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We investigated whether repression of JNK by hepatocyte growth factor/scatter factor (HGF/SF) in MDCK epithelial cells is linked to its ability to protect cells from apoptosis. To this purpose, cells were treated by TNF-alpha, a well-known inducer of JNK and of cell death, and the effects of HGF/SF were investigated under these conditions. We identified repression of JNK as a signaling target of HGF/SF for protection against TNF-alpha-induced cell death. This effect of HGF/SF occurs via the activation of the PI3K and MEK1 pathways.

引用

页码：100 / 103

页数：4