The postoperative clinical outcomes and safety of early enteral nutrition in operated gastric cancer patients

Purpose: This study investigated the impact of early enteral nutrition (EEN) on the clinical outcomes of gastric cancer patients after radical gastrectomy. Methods: Four hundred gastric cancer patients undergoing radical gastrectomy of any extend with D2 nodal dissection were randomly divided into an experimental and a control group with 200 cases in each group. Patients in the control group received postoperative parenteral nutrition (PN), while patients in the experimental group received postoperative EEN. After treatment, the clinical outcomes, postoperative immune function, and nutritional status of the two groups were evaluated. Results: The postoperative fever time, intestinal function recovery time, anal exhaust time, and the length of hospital stay for patients in the experimental group were significantly shorter than those of the control group. We did not find significant differences in anastomotic leak, postoperative ileus and regurgitation between the two groups. The activities of multiple immune cell types, including CD3(+), CD4(+), CD4(+)CD8(+), and natural killer (NK) cells, were significantly lower in both groups on postoperative day 1 when compared with the preoperative levels (p <0.05). The level of CD8(+) was not significantly different between the two groups (p>0.05). After treatment, levels of CD3(+), CD4(+), CD4(+)/CD8(+), and NK cells in the experimental group patients were 35.6 +/- 4.2, 42.2 +/- 3.0, 1.7 +/- 0.3, and 27.3 +/- 5.3%, respectively, on postoperative day 7, which were similar to the preoperative levels. The immune cell levels from the control group patients remained significantly lower when compared with preoperative values; in addition, these values were also significantly lower when compared with the EEN patients (p <0.05) Conclusion: For gastric cancer patients undergoing radical gastrectomy, the clinical outcome, immune function and nutritional status after LEN were significantly improved. These data suggest the widespread use of LEN in clinical practice.