Implementation of [18F] GE-180 for Routine Production on ORA Neptis Perform Synthesizer®

被引：0
|
作者：
Jivan, S. [1 ]
Villeret, G. [2 ]
Neumannn, K. [1 ]
Slater, J. [1 ]
Vanbrocklin, H. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, 185 Berry St, San Francisco, CA 94143 USA
[2] Optimized Radiochem Applicat, Rue Gendarmerie 50-B, B-5600 Philippeville, Belgium
来源：
WTTC16: PROCEEDINGS OF THE 16TH INTERNATIONAL WORKSHOP ON TARGETRY AND TARGET CHEMISTRY | 2017年 / 1845卷
关键词：
TSPO; PET;
D O I：
10.1063/1.4983543
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The aim of this work is to develop a method to produce [F-18] GE-180 on a Neptis Perform Synthesizer (R) module with high radiochemical yield, purity and reproducibility. Herein is described the labelling, HPLC purification and final product formulation. Decay corrected yields of 45 +/- 5% (n=20) were achieved after a 60 minute synthesis. Radiochemical purity was >95% and all other quality control parameters were within specifications.
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页数：3
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