Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise

被引：133
|
作者：
Tench, CM
McCarthy, J
McCurdie, I
White, PD
D'Cruz, DP
机构：
[1] Barts & London Queen Marys Sch Med & Dent, Bone & Joint Res Unit, London, England
[2] Barts & London Queen Marys Sch Med & Dent, Dept Psychol Med, London, England
[3] Natl Sports Med Inst, London, England
[4] Barts & London NHS Trust, London, England
来源：
RHEUMATOLOGY | 2003年 / 42卷 / 09期
关键词：
fatigue; exercise; SLE; randomized controlled trial;
D O I：
10.1093/rheumatology/keg289
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective. To test the efficacy of a graded aerobic exercise programme in treating fatigue in systemic lupus erythematosus. Methods. Ninety-three patients with systemic lupus erythematosus without active disease in any major organ were randomized, using a minimization protocol, to 12 weeks of graded exercise therapy, relaxation therapy or no intervention. Results. Analysis by intention to treat showed that 16 of the 33 (49%) patients in the exercise group rated themselves as 'much' or 'very much' better compared with eight out of 29 (28%) in the relaxation group and five out of 32 (16%) in the control group (chi(2)=8.3, df=2, P=0.02). Fatigue improved significantly on one out of three measures after exercise therapy and there was a trend for fatigue to improve on all measures after exercise. Conclusion. These findings support the use of appropriately prescribed graded aerobic exercise in the management of patients with fatigue and systemic lupus erythematosus.
引用
收藏
页码：1050 / 1054
页数：5
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