共 50 条
- [1] PRECLINICAL DEVELOPMENT OF THE PI3K ALPHA SELECTIVE AND PIK3CA MUTANT SELECTIVE INHIBITOR GDC-0077 AND PREDICTION OF ITS HUMAN PHARMACOKINETICS[J]. DRUG METABOLISM AND PHARMACOKINETICS, 2019, 34 (01) : S37 - S37Pang, Jodie论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USABaumgardner, Matthew论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USABraun, Marie-Gabrielle论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USACheong, Jonathan论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USAEdgar, Kyle论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USAFriedman, Lori论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USAHanan, Emily论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USAJaochico, Allan论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USAMa, Shuguang论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USAPlise, Emile论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USASchmidt, Stephen论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USALiu, Ning论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USASong, Kyung论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USAStaben, Steve论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USASalphati, Laurent论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA USA Genentech Inc, San Francisco, CA USA
- [2] Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (24) : 16589 - 16621Hanan, Emily J.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USABraun, Marie-Gabrielle论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAHeald, Robert A.论文数: 0 引用数: 0 h-index: 0机构: Early Discovery Charles River, Harlow CM19 5TR, Essex, England Artios Pharm, B940 Babraham Res Campus, Cambridge CB22 3FH, England Genentech Inc, South San Francisco, CA 94080 USAMacLeod, Calum论文数: 0 引用数: 0 h-index: 0机构: Early Discovery Charles River, Harlow CM19 5TR, Essex, England Engitix Therapeut, 195 Wood Lane, London W12 7FQ, England Genentech Inc, South San Francisco, CA 94080 USAChan, Connie论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAClausen, Saundra论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAEdgar, Kyle A.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAEigenbrot, Charles论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAElliott, Richard论文数: 0 引用数: 0 h-index: 0机构: Early Discovery Charles River, Harlow CM19 5TR, Essex, England Genentech Inc, South San Francisco, CA 94080 USAEndres, Nicholas论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAFriedman, Lori S.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA ORIC Pharmaceut, 240 E Grand Ave, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAGogol, Emily论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Infinite Tree, 11577 Williams Hwy, Grants Pass, OR 97527 USA Genentech Inc, South San Francisco, CA 94080 USAGu, Xiao-Hui论文数: 0 引用数: 0 h-index: 0机构: Pharmaron Beijing Co Ltd, Beijing 100176, Peoples R China GT Apeiron Therapeut, West Zone,Block C,1976 Middle Gaoke Rd, Shanghai, Peoples R China Genentech Inc, South San Francisco, CA 94080 USAThibodeau, Rebecca Hong论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Codexis Inc, 400 Penobscot Dr, Redwood City, CA 94063 USA Genentech Inc, South San Francisco, CA 94080 USAJackson, Philip S.论文数: 0 引用数: 0 h-index: 0机构: Early Discovery Charles River, Harlow CM19 5TR, Essex, England Genentech Inc, South San Francisco, CA 94080 USAKiefer, James R.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAKnight, Jamie D.论文数: 0 引用数: 0 h-index: 0机构: Early Discovery Charles River, Harlow CM19 5TR, Essex, England Genentech Inc, South San Francisco, CA 94080 USANannini, Michelle论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USANarukulla, Raman论文数: 0 引用数: 0 h-index: 0机构: Early Discovery Charles River, Harlow CM19 5TR, Essex, England Genentech Inc, South San Francisco, CA 94080 USAPace, Amanda论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Walmart Data Ventures, Los Angeles, CA USA Genentech Inc, South San Francisco, CA 94080 USAPang, Jodie论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAPurkey, Hans E.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USASalphati, Laurent论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USASampath, Deepak论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Ultragenyx Pharmaceut, 60 Leveroni Court, Novato, CA 94949 USA Genentech Inc, South San Francisco, CA 94080 USASchmidt, Stephen论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USASideris, Steve论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USASong, Kyung论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USASujatha-Bhaskar, Swathi论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAUltsch, Mark论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAWallweber, Heidi论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAXin, Jianfeng论文数: 0 引用数: 0 h-index: 0机构: Pharmaron Beijing Co Ltd, Beijing 100176, Peoples R China Genentech Inc, South San Francisco, CA 94080 USAYeap, SiewKuen论文数: 0 引用数: 0 h-index: 0机构: Early Discovery Charles River, Harlow CM19 5TR, Essex, England Cresset, New Cambridge House, Litington SG8 0SS, Cambs, England Genentech Inc, South San Francisco, CA 94080 USAYoung, Amy论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA ORIC Pharmaceut, 240 E Grand Ave, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAZhong, Yu论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USAStaben, Steven T.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, South San Francisco, CA 94080 USA Lycia Therapeut, 400 East Jamie Court,Suite 200, South San Francisco, CA 94080 USA Genentech Inc, South San Francisco, CA 94080 USA
- [3] Synthesis of PI3K inhibitor GDC-0077 via a stereocontrolled N-arylation of α-amino acids[J]. TETRAHEDRON, 2019, 75 (32) : 4351 - 4357Han, Chong论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USA Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USAKelly, Sean M.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USA Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USACravillion, Theresa论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USA Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USASavage, Scott J.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USA Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USANguyen, Tina论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USA Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USAGosselin, Francis论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USA Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USA
- [4] Discovery of GDC-0077, a highly isoform selective inhibitor of PI3Kα that promotes selective loss of mutant-p110α[J]. CANCER RESEARCH, 2017, 77Staben, Steven T.论文数: 0 引用数: 0 h-index: 0
- [5] GDC-0077 is a selective PI3K alpha inhibitor with robust efficacy in PIK3CA mutant hormone-positive breast cancer models[J]. CANCER RESEARCH, 2020, 80 (04)Edgar, Kyle论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAHong, Rebecca论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USASong, Kyung论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USASchmidt, Steven论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAHafner, Marc论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAArrazate, Alfonso论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAWilliams, Erin论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USADe La Cruz, Cecile论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAOeh, Jason论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USASampath, Deepak论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAStaben, Steve论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USAFriedman, Lori论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USA
- [6] Discovery of GDC-0077: A highly selective inhibitor of PI3K-alpha that induces degradation of mutant-p110 alpha protein[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256Braun, Marie-Gabrielle论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, San Francisco, CA 94080 USA Genentech Inc, San Francisco, CA 94080 USA
- [7] RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy[J]. CANCER DISCOVERY, 2022, 12 (01) : 204 - 219Song, Kyung W.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAEdgar, Kyle A.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAHanan, Emily J.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Discovery Chem, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAHafner, Marc论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Oncol Bioinformat, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAOeh, Jason论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Translat Oncol, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAMerchant, Mark论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Translat Oncol, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USASampath, Deepak论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Translat Oncol, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USANannini, Michelle A.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Translat Oncol, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAHong, Rebecca论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Translat Oncol, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAPhu, Lilian论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Microchem Prote Lipid, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAForrest, William F.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Oncol Bioinformat, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAStawiski, Eric论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Oncol Bioinformat, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USASchmidt, Stephen论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Biochem & Cell Pharmacol, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAEndres, Nicholas论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Biochem & Cell Pharmacol, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAGuan, Jane论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAWallin, Jeffrey J.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Translat Oncol, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USACheong, Jonathan论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Translat Oncol, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAPlise, Emile G.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Drug Metab & Pharmacokinet, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAPhillips, Gail D. Lewis论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USASalphati, Laurent论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Drug Metab & Pharmacokinet, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAHeffron, Timothy P.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Discovery Chem, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAOlivero, Alan G.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Discovery Chem, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAMalek, Shiva论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAStaben, Steven T.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Discovery Chem, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAKirkpatrick, Donald S.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Microchem Prote Lipid, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USADey, Anwesha论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USAFriedman, Lori S.论文数: 0 引用数: 0 h-index: 0机构: Genentech Inc, Dept Translat Oncol, San Francisco, CA 94080 USA Genentech Inc, Dept Discovery Oncol, 1 DNA Way,MS 41-1a, San Francisco, CA 94080 USA
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