Synthesis and 2D QSAR of O-sulphonated β-aminols derivatives as novel antifungal and antibacterial agents

被引：5
|
作者：
Sharma, Sugandha [1 ]
Pandey, Atindra K. [2 ]
Shukla, Praveen K. [2 ]
Saxena, Anil K. [1 ]
机构：
[1] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India
[2] Cent Drug Res Inst, Fermentat Technol Div, Lucknow 226001, Uttar Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 21期
关键词：
O-sulphonated beta-aminols; Antifungal; Antibacterial; QSAR; EPIDEMIOLOGY; INFECTIONS; EPOXIDES; AMINES;
D O I：
10.1016/j.bmcl.2011.08.078
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Synthesis of a series of beta-aminol derivatives using regioselective opening reaction catalyzed by SiO2 (60-120 mesh) and O-sulphonation in THF-KOH system, comprising tert-butoxycarbonyl at secondary nitrogen and evaluate for various stains of bacteria and fungi. SAR study of synthesized compound using backward regression analysis. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6476 / 6481
页数：6
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