Platelets: a potential role in chronic respiratory diseases?

被引：17
|
作者：
Chebbo, Mohamad [1 ]
Duez, Catherine [1 ]
Alessi, Marie C. [1 ,2 ]
Chanez, Pascal [1 ,3 ]
Gras, Delphine [1 ]
机构：
[1] Aix Marseille Univ, INSERM, INRAE, Marseille, France
[2] CHU Timone, APHM, Lab Hematol, Marseille, France
[3] Hop Nord Marseille, APHM, Clin Bronches Allergie & Sommeil, Marseille, France
来源：
EUROPEAN RESPIRATORY REVIEW | 2021年 / 30卷 / 161期
关键词：
IMPAIRS HOST-DEFENSE; OBSTRUCTIVE PULMONARY-DISEASE; P-SELECTIN; ENDOTHELIAL-CELLS; ADAPTIVE IMMUNITY; DENDRITIC CELLS; NEUTROPHIL INTERACTIONS; STAPHYLOCOCCUS-AUREUS; ASPERGILLUS-FUMIGATUS; MEDIATED MODULATION;
D O I：
10.1183/16000617.0062-2021
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Platelets are small anucleate cells known for their role in haemostasis and thrombosis. In recent years, an increasing number of observations have suggested that platelets are also immune cells and key modulators of immunity. They express different receptors and molecules that allow them to respond to pathogens, and to interact with other immune cells. Platelets were linked to the pathogenesis of some inflammatory disorders including respiratory diseases such as asthma and idiopathic pulmonary fibrosis. Here, we discuss the involvement of platelets in different immune responses, and we focus on their potential role in various chronic lung diseases.
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收藏
页数：17
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