Switching from Intravenous to Subcutaneous Formulation of Abatacept: A Single-center Italian Experience on Efficacy and Safety

被引：13
|
作者：
Reggia, Rossella [1 ,2 ]
Franceschini, Franco [1 ,2 ]
Tincani, Angela [1 ,2 ]
Cavazzana, Ilaria [1 ,2 ]
机构：
[1] Spedali Civil Brescia, Rheumatol & Clin Immunol Dept, I-25125 Brescia, Italy
[2] Univ Brescia, Brescia, Italy
来源：
JOURNAL OF RHEUMATOLOGY | 2015年 / 42卷 / 02期
关键词：
RHEUMATOID ARTHRITIS; THERAPY; ABATACEPT; SUBCUTANEOUS FORMULATION; EFFICACY; SAFETY; ACTIVE RHEUMATOID-ARTHRITIS; LONG-TERM SAFETY; PHASE IIIB; INADEQUATE RESPONSE; TRIAL; METHOTREXATE;
D O I：
10.3899/jrheum.141042
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective. Subcutaneous (SC) abatacept (ABA) is comparable to intravenous (IV) formulation in terms of efficacy and safety profile. Our work analyzed the switch to SC formulation from IV administration in patients with rheumatoid arthritis. Methods. Fifty-one patients treated with SC ABA were included. Clinical data were obtained from clinical charts. Results. Fourteen patients relapsed and needed to return to the IV administration. Neither clinical and laboratory features nor the previous therapies were identified as risk factors for SC formulation inefficacy. Disease activity decreased after the return to IV infusions. Conclusion. SC ABA showed a risk of relapse in 27% of cases. The reinsertion of the IV administration quickly reinstated disease control.
引用
收藏
页码：193 / 195
页数：3
相关论文
共 50 条
  • [1] Efficacy of the Subcutaneous Formulation of Abatacept/Orencia in Rheumatoid Arthritis, a Single-Center Italian Experience.
    Reggia, Rossella
    Franceschini, Franco
    Tincani, Angela
    Cavazzana, Ilaria
    ARTHRITIS & RHEUMATOLOGY, 2014, 66 : S675 - S675
  • [2] Safety and efficacy of transitioning inflammatory bowel disease patients from intravenous to subcutaneous infliximab: a single-center real-world experience
    Jeffrey, Angus W.
    Abu-Rgeef, Reeham
    Picardo, Sherman
    Menon, Shankar
    So, Kenji
    Venugopal, Kannan
    ANNALS OF GASTROENTEROLOGY, 2023, : 549 - 554
  • [3] Switching from Intravenous to Subcutaneous Formulation of Abatacept: Different Results in a Series of 21 Patients
    Monti, Sara
    Breda, Silvia
    Grosso, Vittorio
    Todoerti, Monica
    Montecucco, Carlomaurizio
    Caporali, Roberto
    JOURNAL OF RHEUMATOLOGY, 2015, 42 (10) : 1993 - +
  • [4] Switching from Intravenous to Subcutaneous Formulation of Abatacept: Different Results in a Series of 21 Patients reply
    Reggia, Rossella
    Franceschini, Franco
    Cavazzana, Ilaria
    JOURNAL OF RHEUMATOLOGY, 2015, 42 (10) : 1995 - 1995
  • [5] Switch from intravenous to subcutaneous abatacept: Our experience
    Carlos Nieto-Gonzalez, Juan
    Ovalles-Bonilla, Juan G.
    Estrada, Eduardo
    Monteagudo, Indalecio
    REUMATOLOGIA CLINICA, 2020, 16 (02): : 187 - 188
  • [6] REAL CLINICAL EXPERIENCE WITH ABATACEPT, FROM INTRAVENOUS TO SUBCUTANEOUS
    Nieto-Gonzalez, J. C.
    Janta, I.
    Ovalles-Bonilla, J. G.
    Serrano, B.
    Mata, C.
    Gonzalez-Benitez, R.
    Valor, L.
    Lopez-Longo, F. J.
    Gonzalez-Fernandez, C. M.
    Monteagudo, I.
    Naredo, E.
    ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 : 1024 - 1024
  • [7] FAILURE OF THE SWITCH FROM THE INTRAVENOUS TO THE SUBCUTANEOUS FORMULATION OF ABATACEPT DUE TO A DISEASE REACTIVATION: OUR EXPERIENCE
    Reggia, R.
    Cavazzana, I.
    Tincani, A.
    Franceschini, F.
    ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 : 732 - 732
  • [8] Letter: Experience of switching vedolizumab treatment from intravenous to subcutaneous formulation in Hungary
    Bacsur, Peter
    Ilias, Akos
    Resal, Tamas
    Kata, Diana
    Molnar, Tamas
    Farkas, Klaudia
    ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2023, 58 (02) : 262 - 263
  • [9] Safety and Efficacy of Surgery for Metastatic Tumor to the Pancreas: A Single-Center Experience
    Moletta, Lucia
    Friziero, Alberto
    Serafini, Simone
    Grillo, Valeria
    Pierobon, Elisa Sefora
    Capovilla, Giovanni
    Valmasoni, Michele
    Sperti, Cosimo
    JOURNAL OF CLINICAL MEDICINE, 2023, 12 (03)
  • [10] Efficacy and Safety of Ultrafiltration in Patients with Heart Failure: A Single-Center Experience
    Shen Xiangli
    Li Lan
    Zu Libiya
    Ma Jun
    Jiang Shubin
    ADVANCES IN THERAPY, 2022, 39 (10) : 4523 - 4532
12345