First phase I clinical trial of an HIV-1 subtype D gp140 envelope protein vaccine: immune activity induced in all study participants

被引：9

作者：

Huritz, Julia L. ^{[1
,2
,4
]}

Lockey, Timothy D. ^{[1
,3
]}

Jones, Bart ^{[1
,2
]}

Freiden, Pamela ^{[2
]}

Sealy, Robert ^{[1
,2
]}

Coleman, John ^{[3
]}

Howlett, Nanna ^{[2
]}

Branum, Kristen ^{[2
]}

Slobod, Karen S. ^{[2
,5
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN USA

[3] St Jude Childrens Res Hosp, Dept Therapeut Prod & Quality, Memphis, TN USA

[4] Univ Tennessee, Dept Pathol, Knoxville, TN 37996 USA

[5] Univ Tennessee, Hlth Sci Ctr, Dept Pediat, Knoxville, TN 37996 USA

来源：

AIDS | 2008年 / 22卷 / 01期

关键词：

D O I：

10.1097/QAD.0b013e3282f174ed

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To combat HIV-1 diversity, we are developing a multienvelope vaccine (comprising DNA, vaccinia virus and protein vectors). Toward this goal, we conducted a phase I clinical trial of EnvPro, a gp140 protein formulated in alum. The vaccine was well tolerated and elicited an immune response in every trial participant.

引用

页码：149 / 151

页数：3

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