Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation

被引：9

作者：

Bergamaschi, D ^{[1
]}

Samuels, Y ^{[1
]}

Zhong, S ^{[1
]}

Lu, X ^{[1
]}

机构：

[1] UCL, Ludwig Inst Canc Res, London W1W 7BS, England

来源：

ONCOGENE | 2005年 / 24卷 / 23期

关键词：

ASPP; p53; mdm2; mdmX; apoptosis; transactivation;

D O I：

10.1038/sj.onc.1208535

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using various mutants of p53 and mdm2, we demonstrate here that both the DNA binding and transactivation function of p53 are required for ASPP1 and ASPP2 to stimulate the apoptotic functions of p53. Mdm2 and mdmx prevent ASPP1 and ASPP2 from stimulating the apoptotic function of p53 by binding and inhibiting the transcriptional activity of p53. Importantly, mdm2 and mdmx can prevent the stimulatory effects of ASPP1 and ASPP2 without targeting p53 for degradation. These data provide a novel mechanism by which mdm2 and mdmx act as potent inhibitors of p53.

引用

页码：3836 / 3841

页数：6

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