Aggregation-Induced Emission-Active Biomacromolecules: Progress, Challenges, and Opportunities

Biomacromolecules featuring aggregation-induced-emission (AIE) characteristics generally present new properties and performances that are silent in the molecular state, providing endless possibilities for the evolution of biomedical applications. Tremendous achievements based on the research of ME-active biomacromolecules have been made in synthetic exploration, material development, and practical applications. In this Perspective, we give a brief account in the development of AIE-active biomacromolecules. Remarkable progresses have been made in the exploration of AIE-active biomacromolecule preparation, structure-property relationships, and the relevant biomedical applications. The existing challenges and promising opportunities, as well as the future directions in ME-active biomacromolecule research, are also discussed. It is expected that this Perspective can act as a trigger for the innovation of AIE-active biomacromolecule research and aggregate science.