Adaptive evolution in the snake venom Kunitz/BPTI protein family

被引：114
|
作者：
Zupunski, V
Kordis, D
Gubensek, F
机构：
[1] Jozef Stefan Inst, Dept Biochem & Mol Biol, Ljubljana 1000, Slovenia
[2] Univ Ljubljana, Dept Chem & Biochem, Fac Chem & Chem Technol, Ljubljana, Slovenia
来源：
FEBS LETTERS | 2003年 / 547卷 / 1-3期
关键词：
Kunitz/BPTI homolog; snake venom; multigene family; adaptive evolution;
D O I：
10.1016/S0014-5793(03)00693-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Snake venoms are rich sources of serine proteinase inhibitors that are members of the Kunitz/BPTI (bovine pancreatic trypsin inhibitor) family. However, only a few of their gene sequences have been determined from snakes. We therefore cloned the cDNAs for the trypsin and chymotrypsin inhibitors from a Vipera ammodytes venom gland cDNA library. Phylogenetic analysis of these and other snake Kunitz/BPTI homologs shows the presence of three clusters, where sequences cluster by functional role. Analysis of the nucleotide sequences from the snake Kunitz/BPTI family shows that positive Darwinian selection was operating on the highly conserved BPTI fold, indicating that this family evolved by gene duplication and rapid diversification. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：131 / 136
页数：6
相关论文
共 50 条
  • [1] Strong and widespread action of site-specific positive selection in the snake venom Kunitz/BPTI protein family
    Zupunski, Vera
    Kordis, Dusan
    SCIENTIFIC REPORTS, 2016, 6
  • [2] Strong and widespread action of site-specific positive selection in the snake venom Kunitz/BPTI protein family
    Vera Župunski
    Dušan Kordiš
    Scientific Reports, 6
  • [3] THE IMPACT OF SITE-SPECIFIC POSITIVE SELECTION ON THE STRUCTURALLY AND FUNCTIONALLY IMPORTANT PARTS OF THE SNAKE VENOM KUNITZ/BPTI PROTEIN FAMILY
    Zupunski, Vera
    Kordis, Dusan
    TOXICON, 2019, 159 : S4 - S4
  • [4] Foci of amino acid residue conservation in the 3D structures of the Kunitz BPTI proteinase inhibitors: How do variants from snake venom differ?
    Cardle, L
    Dufton, MJ
    PROTEIN ENGINEERING, 1997, 10 (02): : 131 - 136
  • [5] Diet and snake venom evolution
    Daltry, JC
    Wuster, W
    Thorpe, RS
    NATURE, 1996, 379 (6565) : 537 - 540
  • [6] SNAKE-VENOM EVOLUTION
    STRYDOM, DJ
    SOUTH AFRICAN JOURNAL OF SCIENCE, 1977, 73 (03) : 70 - 70
  • [7] Evolution, expansion and expression of the Kunitz/BPTI gene family associated with long-term blood feeding in Ixodes Scapularis
    Shao-Xing Dai
    Ai-Di Zhang
    Jing-Fei Huang
    BMC Evolutionary Biology, 12
  • [8] Evolution, expansion and expression of the Kunitz/BPTI gene family associated with long-term blood feeding in Ixodes Scapularis
    Dai, Shao-Xing
    Zhang, Ai-Di
    Huang, Jing-Fei
    BMC EVOLUTIONARY BIOLOGY, 2012, 12
  • [9] Protein complexes in snake venom
    R. Doley
    R. M. Kini
    Cellular and Molecular Life Sciences, 2009, 66 : 2851 - 2871
  • [10] Protein complexes in snake venom
    Doley, R.
    Kini, R. M.
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2009, 66 (17) : 2851 - 2871
12345