Hydrotalcite: A novel and reusable solid catalyst for one-pot synthesis of 3,4-dihydropyrimidinones and mechanistic study under solvent free conditions

被引：66

作者：

Lal, Jaggi ^{[1
]}

Sharma, Monika ^{[1
]}

Gupta, Savita ^{[2
]}

Parashar, Priyanka ^{[1
]}

Sahu, Pramod ^{[1
]}

Agarwal, D. D. ^{[1
]}

机构：

[1] Jiwaji Univ, Dept Ind Chem, Gwalior 474011, India

[2] Cadila Pharmaceut Ltd, Ahmadabad 382210, Gujarat, India

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2012年 / 352卷

关键词：

Dihydropyrimidinones; Multicomponent synthesis; Mg-Al-CO3 and Ca-Al-CO3 hydrotalcite catalyst; Solvent free; Microwave irradiations; Mechanistic study; BIGINELLI REACTION; POLYTYPE DIVERSITY; EFFICIENT CATALYST; IMPROVED PROTOCOL; ANIONIC CLAYS; CONDENSATION; DIHYDROPYRIMIDIN-2(1H)-ONES; TETRAFLUOROBORATE; MINERALS; SYSTEM;

D O I：

10.1016/j.molcata.2011.09.009

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Synthesis of 3,4-dihydropyrimidinones/thiones, a multicomponent synthesis using ethyl acetoacetate, substituted aromatic aldehydes, and urea/thiourea has been carried out in presence of Mg-Al-CO3 and Ca-Al-CO3 hyclrotalcite as a reusable solid catalyst. The work has been carried out under thermal solvent-free conditions without microwave irradiations, and under microwave irradiation. In this method excellent yield of 3,4-dihydropyrimidinones/thiones is reported in shorter duration. Hydrotalcites are non-toxic, easy to separate and recyclable catalyst hence making this process environment friendly. Mechanistic study of the reaction using hydrotalcites as catalyst has been studied under thermal conditions without microwave irradiations. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：31 / 37

页数：7

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