Learning objectives Upon completion of this activity, participants will be able to: Compare anatomical success rate between air and 20% SF6 tamponade in 27GPPV for RRD, according to a retrospective, observational, and consecutive study. Compare visual outcomes and changes in intraocular pressure during 12-month follow-up between air and 20% SF6 tamponade in 27GPPV for RRD, according to a retrospective, observational, and consecutive study. Compare type and frequency of complications during 12-month follow-up between air and 20% SF6 tamponade in 27GPPV for RRD, according to a retrospective, observational, consecutive study, and describe other clinical implications regarding surgical outcomes. Accreditation Statements In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Springer Nature. Medscape, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. Medscape, LLC designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)(TM). Physicians should claim only the credit commensurate with the extent of their participation in the activity. Credit Hours 1.0 Release date: 20 December 2019 Expiration date: 20 December 2020 Post-test link: Authors/Editors disclosure information A.T. has disclosed no relevant financial relationships. H.I. has disclosed the following relevant financial relationships: received grants for clinical research from: Alcon Japan. M.H. has disclosed no relevant financial relationships. K.O. has disclosed no relevant financial relationships. W. M. has disclosed no relevant financial relationships. A.M. has disclosed no relevant financial relationships. M.N. has disclosed the following relevant financial relationships: received grants for clinical research from: Alcon Japan; Otsuka Pharmaceuticals. Sobha Sivaprasad (Editor) has disclosed the following relevant financial relationships: Served as an advisor or consultant for: Allergan, Inc.; Bayer AG; Boehringer Ingelheim Pharmaceuticals, Inc.; Heidelberg Pharma GmbH; Optos; Roche. Served as a speaker or a member of a speakers bureau for: Allergan, Inc.; Bayer AG; Novartis Pharmaceuticals Corporation; Optos. Received grants for clinical research from: Allergan, Inc.; Bayer AG; Boehringer Ingelheim Pharmaceuticals, Inc.; Novartis Pharmaceuticals Corporation; Optos. Journal CME author disclosure information Laurie Barclay has disclosed no relevant financial relationships. Objectives To compare the surgical results between air and 20% sulfur hexafluoride (SF6) tamponade in 27-gauge pars plana vitrectomy (27GPPV) for rhegmatogenous retinal detachment (RRD). Methods A retrospective, observational, and consecutive study. All patients underwent 27GPPV for RRD were divided into two groups. Group A comprised patients who underwent 20% SF6 gas tamponade. Group B comprised patients who underwent air tamponade. The anatomical success rate, visual outcome, and the type and frequency of complications were investigated and compared between the groups. All patients were followed-up for 12 months after surgery. Results Seventy eyes were enrolled (Group A: 35 eyes, Group B: 35 eyes). Seventeen eyes in Group A and 13 eyes in Group B had RRD with superior retinal breaks, while 14 eyes in Group A and 19 eyes in Group B had RRD with inferior retinal breaks. There was no statistically difference in preoperative demographic date between the groups. The initial and final anatomical success rates were 97.1% and 100% in Group A and 94.3% and 100% in Group B, respectively. The success rates between the groups were not statistically different (p = 1). The best corrected visual acuity (BCVA) (logMAR) at 12 months after surgery was -0.02 +/- 0.14 in Group A and -0.03 +/- 0.27 in Group B. The BCVA between the groups was not statistically different (p = 0.27). Conclusions The surgical results of air tamponade were not inferior to 20% SF6 tamponade in 27GPPV for RRD irrespective of retinal break locations in the present cohort.