Matrix Metalloproteinase-9 (MMP-9) in Children with Dengue Virus Infection

被引：0
|
作者：
Voraphani, Nipasiri
Khongphatthanayothin, Apichai
Srikaew, Karakade [2 ]
Tontulawat, Praewpilai
Poovorawan, Yong [1 ]
机构：
[1] Chulalongkorn Univ, Ctr Excellence Clin Virol, Dept Pediat, Fac Med, Bangkok 10330, Thailand
[2] Hadyai Hosp, Songkhla, Thailand
来源：
JAPANESE JOURNAL OF INFECTIOUS DISEASES | 2010年 / 63卷 / 05期
关键词：
VASCULAR LEAKAGE; FEVER;
D O I：
暂无
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The purpose of this study was to investigate the role of matrix metalloproteinase-9 (MMP-9) in the pathogenesis of vascular leakage in patients with dengue virus infection. Serum samples from 24 children with serologically confirmed dengue virus infection (dengue fever [DF], 16; dengue hemorrhagic fever [DHF], 8; age, 9.5 +/- 2.4 years; 67% male) were analyzed for MMP-9 during the febrile and toxic stages and at follow-up. Serum samples obtained from 7 healthy children were used as controls. Serum MMP-9 levels in patients with dengue virus infection were found to be lower at the febrile (227.0 +/- 186.9 ng/ml) and toxic stages (150.9 +/- 151.7 ng/ml) than at follow-up (424.5 +/- 227.8 ng/ml) or in the control group (393.3 +/- 125.9 ng/ml, P < 0.001 by one-way ANOVA). There was no significant difference between MMP-9 levels in patients with DHF and those with DF at any stage of the disease. In conclusion, MMP-9 levels are reduced during the febrile and toxic stages of dengue virus infection.
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页码：346 / 348
页数：3
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