New approaches to the endocrine prevention and treatment of breast cancer

被引：24
|
作者：
Howell, A
Howell, SJ
Evans, DG
机构：
[1] Univ Manchester, Christie Hosp NHS Trust, CRUK Dept Med Oncol, Manchester M20 4BX, Lancs, England
[2] St Marys Hosp, Dept Clin Genet, Manchester M13 0JH, Lancs, England
来源：
CANCER CHEMOTHERAPY AND PHARMACOLOGY | 2003年 / 52卷 / Suppl 1期
关键词：
breast cancer; prevention; treatment; endocrine;
D O I：
10.1007/s00280-003-0645-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
All major endocrine prevention approaches act via the estrogen receptor (ER). A simple hypothesis concerning ER expression and breast cancer risk is outlined. We review breast cancer prevention trials with tamoxifen. raloxifene, aromatase inhibitors, and ovarian suppression. Current and planned endocrine prevention trials in populations of pre- and postmenopausal women at risk of breast cancer are summarized and endocrine therapy after primary surgery and for advanced disease discussed.
引用
收藏
页码：S39 / S44
页数：6
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