Plasma Creatinine Level Does Not Predict Respiratory Function in Amyotrophic Lateral Sclerosis

被引：2

作者：

Morgadinho, Joao ^{[1
]}

Pronto-Laborinho, Ana Catarina ^{[1
]}

Conceicao, Vasco A. ^{[1
]}

Gromicho, Marta ^{[1
]}

Pinto, Susana ^{[1
]}

Swash, Michael ^{[1
,2
,3
]}

de Carvalho, Mamede ^{[1
,4
]}

机构：

[1] Univ Lisbon, Fac Med, Inst Fisiol, Inst Med Mol Joao Lobo Antunes, Lisbon, Portugal

[2] Queen Mary Univ London, Barts & London Sch Med, Dept Neurol, London, England

[3] Queen Mary Univ London, Barts & London Sch Med, Dept Neurosci, London, England

[4] Ctr Hosp Lisboa Cent, Dept Neurol, Lisbon, Portugal

来源：

JOURNAL OF NEUROMUSCULAR DISEASES | 2021年 / 8卷 / 05期

关键词：

Amyotrophic lateral sclerosis; creatinine; progression; respiratory function; survival; DISEASE PROGRESSION;

D O I：

10.3233/JND-200583

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In amyotrophic lateral sclerosis (ALS) lower plasma creatinine level has been associated with shorter survival and faster functional decline. It has not been clear if creatinine is associated with respiratory outcome. We analyzed retrospectively a population of unselected ALS patients. Multiple-regression and Cox-regression analyses were performed. We included 233 patients, mean age 62.8, mean disease duration of 18.6 months. At baseline, creatinine was significantly associated with ALSFRS-R, but not with its decline rate. No predictive value was disclosed for FVC, its decline rate, or with survival. We did not confirm that creatinine is a marker of respiratory outcome.

引用

页码：795 / 799

页数：5

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