Neurodevelopmental outcomes of very preterm infants who received cord milking at birth: a randomized controlled trial

被引:3
|
作者
El-Naggar, Walid [1 ]
McMillan, Douglas [1 ]
Hussain, Arif [2 ]
Armson, Anthony [3 ]
Dodds, Linda [4 ,5 ]
Warren, Andrew [2 ]
Whyte, Robin [1 ]
Vincer, Michael [1 ,3 ]
Simpson, C. David [1 ]
机构
[1] Dalhousie Univ, IWK Hlth Ctr, Dept Pediat, Div Neonatal Perinatal Med, 5850-5980 Univ Ave,POB 9700, Halifax, NS B3K 6R8, Canada
[2] Dalhousie Univ, Dept Pediat, Div Cardiol, Halifax, NS, Canada
[3] Dalhousie Univ, Dept Obstet & Gynecol, Halifax, NS, Canada
[4] Dalhousie Univ, Dept Obstet & Gynecol, Perinatal Epidemiol Res Unit, Halifax, NS, Canada
[5] Dalhousie Univ, Dept Pediat, Halifax, NS, Canada
关键词
Early cord clamping; Umbilical cord milking; Long-term neurodevelopmental outcomes; Preterm infants; IMPROVES NEONATAL ADAPTATION; RED-CELL TRANSFUSIONS; UMBILICAL-CORD; CARDIOPULMONARY-RESUSCITATION; INDOMETHACIN PROPHYLAXIS; PLACENTAL TRANSFUSION; NEED; ASSOCIATION; BORN;
D O I
10.1007/s00431-022-04638-x
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Umbilical cord milking improves postnatal adaptation and short-term outcomes of very preterm infants compared to early cord clamping. Little is known about the impact of umbilical cord milking on long-term neurodevelopmental outcomes. The objective of this study is to compare the effects of intact umbilical cord milking (UCM) vs. early cord clamping (ECC) at birth on neurodevelopmental outcomes at 36 months' corrected age. Preterm infants < 31 weeks' gestation who were randomized at birth to receive three time milking of their attached cord or ECC (< 10 s) were evaluated at 36 months' corrected age. Neurodevelopmental outcomes were assessed by blinded examiners using Bayley Scales of Infant and Toddler Development (version III). Analysis was by intention to treat. Out of the 73 infants included in the original trial, 2 died and 65 (92%) infants were evaluated at 36 months' corrected age. Patient characteristics and short-term outcomes were similar in both study groups. There were no significant differences in the median cognitive, motor or language scores or in the rates of cerebral palsy, developmental impairment, deafness, or blindness between study groups. Conclusion: Neurodevelopmental outcomes at 36 months' corrected age of very preterm infants who received UCM were not shown to be significantly different from those who received ECC at birth.
引用
收藏
页码:4215 / 4220
页数:6
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