Complement C1s inhibition with sutimlimab results in durable response in cold agglutinin disease: CARDINAL study 1-year interim follow-up results

被引：22

作者：

Roeth, Alexander ^{[1
]}

Barcellini, Wilma ^{[2
]}

D'Sa, Shirley ^{[3
]}

Miyakawa, Yoshitaka ^{[4
]}

Broome, Catherine M. ^{[5
]}

Michel, Marc ^{[6
]}

Kuter, David J. ^{[7
]}

Jilma, Bernd ^{[8
]}

Tvedt, Tor Henrik Anderson ^{[9
]}

Weitz, Ilene C. ^{[10
]}

Patel, Parija ^{[11
]}

Jiang, Xiaoyu ^{[11
]}

Reuter, Caroline ^{[11
]}

Su, Jun ^{[11
]}

Shafer, Frank ^{[11
]}

Lee, Michelle ^{[11
]}

Berentsen, Sigbjorn ^{[12
]}

机构：

[1] Univ Duisburg Essen, Univ Hosp Essen, Dept Hematol & Stem Cell Transplantat, West German Canc Ctr, Essen, Germany

[2] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy

[3] Univ Coll London Hosp NHS Fdn Trust, UCLH Ctr Waldenstroms Macroglobulinemia & Related, London, England

[4] Saitama Med Univ Hosp, Thrombosis & Hemostasis Ctr, Saitama, Japan

[5] MedStar Georgetown Univ Hosp, Div Hematol, Washington, DC USA

[6] UPEC, Henri Mondor Univ Hosp, Assistance Publ Hop Paris, Creteil, France

[7] Harvard Med Sch, Massachusetts Gen Hosp, Div Hematol, Boston, MA USA

[8] Med Univ Vienna, Dept Clin Pharmacol, Vienna, Austria

[9] Haukeland Hosp, Sect Hematol, Dept Med, Bergen, Norway

[10] USC, Keck Sch Med, Los Angeles, CA USA

[11] Sanofi, Cambridge, MA USA

[12] Haugesund Hosp, Dept Res & Innovat, Haugesund, Norway

来源：

HAEMATOLOGICA | 2022年 / 107卷 / 07期

关键词：

FUNCTIONAL ASSESSMENT; THERAPY; RITUXIMAB;

D O I：

10.3324/haematol.2021.279812

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：1698 / 1702

页数：5

共 50 条

[1] INHIBITION OF COMPLEMENT C1S WITH SUTIMLIMAB IN PATIENTS WITH COLD AGGLUTININ DISEASE (CAD): INTERIM RESULTS OF THE PHASE 3 CARDINAL STUDY LONG -TERM FOLLOW-UP
Barcellinia, W.
Roeth, A.
D'Sa, S.
Miyakawa, Y.
Broome, C. M.
Michel, M.
Kuter, D. J.
Jilma, B.
Tvedt, T. H. Anderson
Weitz, I. C.
Patel, P.
Jiang, X.
Reuter, C.
Su, J.
Shafer, F.
Lee, M.
Hobbsb, W.
Berentsen, S.
[J]. HAEMATOLOGICA, 2021, 106 (10) : 107 - 107
[2] Inhibition of Complement C1s with Sutimlimab in Patients with Cold Agglutinin Disease (CAD): Interim Results of the Phase 3 Cardinal Study Long-Term Follow-up
Roth, Alexander
Barcellini, Wilma
D'Sa, Shirley
Miyakawa, Yoshitaka
Broome, Catherine M.
Michel, Marc
Kuter, David J.
Jilma, Bernd
Tvedt, Tor Henrik Anderson
Weitz, Ilene C.
Patel, Parija
Jiang, Xiaoyu
Reuter, Caroline
Su, Jun
Shafer, Frank
Lee, Michelle
Hobbs, William
Berentsen, Sigbjorn
[J]. BLOOD, 2020, 136
[3] Interim results of the phase 3 CARDINAL study long-term follow-up: Inhibition of complement C1s with sutimlimab in patients with Cold Agglutinin Disease (CAD)
Roeth, A.
Barcellini, W.
D'Sa, S.
Miyakawa, Y.
Broome, C.
Michel, M.
Kuter, D.
Jilma, B.
Tvedt, T. H. A.
Weitz, I. C.
Patel, P.
Jiang, X.
Reuter, C.
Su, J.
Shafer, F.
Lee, M.
Hobbs, W.
Berentsen, S.
[J]. ONCOLOGY RESEARCH AND TREATMENT, 2021, 44 : 169 - 170
[4] Inhibition of Complement C1s with Sutimlimab in Patients with Cold Agglutinin Disease (CAD): Results from the Phase 3 Cardinal Study
Roth, Alexander
Barcellini, Wilma
D'Sa, Shirley
Miyakawa, Yoshitaka
Broome, Catherine M.
Michel, Marc
Kuter, David J.
Jilma, Bernd
Tvedt, Tor Henrik Anderson
Lin, Stella
Jiang, Xiaoyu
Reuter, Caroline
Hobbs, William
Berentsen, Sigbjorn
[J]. BLOOD, 2019, 134
[5] INHIBITION OF COMPLEMENT C1S WITH SUTIMLIMAB IN PATIENTS WITH COLD AGGLUTININ DISEASE (CAD): RESULTS FROM THE PHASE 3 CARDINAL STUDY
Roeth, A.
Barcellini, W.
D'Sa, S.
Miyakawa, Y.
Broome, C. M.
Michel, M.
Kuter, D. J.
Jilma, B.
Tvedt, T. H. Anderson
Lin, S.
Jiang, X.
Reuter, C.
Hobbs, W.
Berentsen, S.
[J]. HAEMATOLOGICA, 2020, 105 : S38 - S38
[6] Results from the phase 3 Cardinal study part A: Inhibition of complement C1s with Sutimlimab in patients with Cold Agglutinin Disease (CAD)
Roeth, A.
Barcellini, W.
Sa, D. S.
Miyakawa, Y.
Broome, C. M.
Michel, M.
Kuter, D. J.
Jilma, B.
Tvedt, Anderson T. H.
Lin, S.
Jiang, X.
Reuter, C.
Hobbs, W.
Berentsen, S.
[J]. ONCOLOGY RESEARCH AND TREATMENT, 2020, 43 (SUPPL 4) : 177 - 177
[7] Sustained inhibition of complement C1s with sutimlimab over 2 years in patients with cold agglutinin disease
Roeth, Alexander
Barcellini, Wilma
D'Sa, Shirley
Miyakawa, Yoshitaka
Broome, Catherine M.
Michel, Marc
Kuter, David J.
Jilma, Bernd
Tvedt, Tor Henrik Anderson
Weitz, Ilene C.
Yoo, Ronnie
Jayawardene, Deepthi
Vagge, Deepthi S.
Kralova, Katarina
Shafer, Frank
Wardecki, Marek
Lee, Michelle
Berentsen, Sigbjorn
[J]. AMERICAN JOURNAL OF HEMATOLOGY, 2023, 98 (08) : 1246 - 1253
[8] Sutimlimab, a complement C1s inhibitor, improves quality of life in patients with cold agglutinin disease: Patient-reported outcomes results of the phase 3 cardinal study
Roeth, A.
Barcellini, W.
Tvedt, Anderson T. H.
Miyakawa, Y.
Kuter, D. J.
Hobbs, W.
Su, J.
Jiang, X.
Arias, Morales J.
Weitz, I. C.
[J]. ONCOLOGY RESEARCH AND TREATMENT, 2020, 43 (SUPPL 4) : 179 - 180
[9] SUTIMLIMAB, A COMPLEMENT C1S INHIBITOR, IMPROVES QUALITY OF LIFE IN PATIENTS WITH COLD AGGLUTININ DISEASE: PATIENT-REPORTED OUTCOMES RESULTS OF THE PHASE 3 CARDINAL STUDY
Barcellini, W.
Roth, A.
Tvedt, T. H. Anderson
Miyakawa, Y.
Kuter, D. J.
Hobbs, W.
Su, J.
Jiang, X.
Morales Arias, J.
Weitz, I. C.
[J]. HAEMATOLOGICA, 2021, 106 (10) : 111 - 112
[10] Sutimlimab: A Complement C1s Inhibitor for the Management of Cold Agglutinin Disease-Associated Hemolysis
Moore, Donald C.
Arnall, Justin R.
[J]. ANNALS OF PHARMACOTHERAPY, 2023, 57 (08) : 970 - 977

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