The effect of malaria on stunting: an instrumental variables approach

被引:0
|
作者
Ateba, Francois Freddy [1 ,2 ,3 ]
Doumbia, Seydou [1 ,2 ]
Ter Kuile, Feiko O. [4 ,5 ]
Terlouw, Dianne J. [4 ,6 ]
Lefebvre, Genevieve [3 ]
Kariuki, Simon [5 ]
Small, Dylan S. [7 ]
机构
[1] Univ Sci Tech & Technol Bamako, Fac Med & Odontostomatol, Malaria Res & Training Ctr, BP 1805 Point G, Bamako, Mali
[2] Univ Sci Tech & Technol Bamako, Fac Med & Odontostomatol, Dept Publ Hlth Educ & Res, BP 1805 Point G, Bamako, Mali
[3] Univ Quebec Montreal UQAM, Dept Math, Montreal, PQ H2X 3Y7, Canada
[4] Univ Liverpool Liverpool Sch Trop Med, Dept Clin Sci, Pembroke Pl, Liverpool L3 5QA, Merseyside, England
[5] Kenya Med Res Inst KEMRI, Ctr Global Hlth Res, POB 1578, Kisumu 40100, Kenya
[6] Malawi Liverpool Wellcome Trust Clin Res Programm, POB 30096, Blantyre, Malawi
[7] Univ Penn, Wharton Sch, Dept Stat, 464 Jon M Huntsman Hall 3730 Walnut St, Philadelphia, PA 19104 USA
基金
美国国家卫生研究院;
关键词
ITNs; IV; LiST model; malaria; TREATED BED NETS; MENDELIAN RANDOMIZATION; EPIDEMIOLOGY; CHILDREN; GROWTH; TRANSMISSION; INFERENCE; AREA;
D O I
10.1093/trstmh/traa183
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: Previous studies have found mixed evidence for an effect of malaria on stunting, but have suffered from concerns about confounding and/or power. Currently, an effect of malaria on stunting is not included in the Lives Saved Tool (LiST) model. Methods: We used instrumental variables regression with the sickle cell trait and random assignment to bednets as instruments in the analysis of data on children aged 0-2 y from a bednet trial in western Kenya. Results: We estimated that one additional clinical malaria episode per year increases the odds of a child being stunted by 6% (OR estimate: 1.06, 95% CI 1.01 to 1.11). Conclusions: Our finding that malaria affects stunting suggests that an effect of malaria on stunting in young children should be considered in the LiST model.
引用
收藏
页码:1094 / 1098
页数:5
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