THE EFFICACY OF CEDIRANIB AS MONOTHERAPY AND IN COMBINATION WITH LOMUSTINE COMPARED TO LOMUSTINE ALONE IN PATIENTS WITH RECURRENT GLIOBLASTOMA: A PHASE III RANDOMIZED STUDY

被引:0
|
作者
Batchelor, Tracy [1 ]
Mulholland, Paul [2 ]
Neyns, Bart [3 ]
Nabors, L. B. [4 ]
Campone, Mario [5 ]
Wick, Antje [6 ]
Mason, Warren [7 ]
Mikkelsen, Tom [8 ]
Phuphanich, Surasek [9 ]
Ashby, Lynn S. [10 ]
DeGroot, John F. [11 ]
Gattamancni, H. R. [12 ]
Cher, Lawrence M.
Rosenthal, Mark A. [13 ]
Payer, Franz [14 ]
Xu, John [15 ]
Liu, Qi [15 ]
van den Bent, Martin [16 ]
机构
[1] Massachusetts Gen Hosp, Boston, MA 02114 USA
[2] UCL, London, England
[3] Univ Ziekenhuis Brussel, Brussels, Belgium
[4] Univ Alabama, Neurooncol Program, Birmingham, AL USA
[5] Ctr Rene Gauducheau, St Herblain, France
[6] Univ Heidelberg, D-6900 Heidelberg, Germany
[7] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada
[8] Henry Ford Hosp, Detroit, MI 48202 USA
[9] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
[10] Barrow Neurol Inst, Phoenix, AZ 85013 USA
[11] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[12] Christie Fdn Trust Hosp, Manchester, Lancs, England
[13] Royal Melbourne Hosp, Melbourne, Vic, Australia
[14] Med Univ Graz, Graz, Austria
[15] AstraZeneca, Wilmington, NC USA
[16] Erasmus Univ Hosp, Daniel den Hoed Canc Ctr, Rotterdam, Netherlands
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:75 / 75
页数:1
相关论文
共 50 条
  • [1] A PHASE III RANDOMIZED STUDY COMPARING THE EFFICACY OF CEDIRANIB AS MONOTHERAPY, AND IN COMBINATION WITH LOMUSTINE, WITH LOMUSTINE ALONE IN RECURRENT GLIOBLASTOMA PATIENTS
    Batchelor, T.
    Mulholland, P.
    Neyns, B.
    Nabors, L. B.
    Campone, M.
    Wick, A.
    Mason, W.
    Xu, J.
    Liu, Q.
    van den Bent, M.
    [J]. ANNALS OF ONCOLOGY, 2010, 21 : 4 - 4
  • [2] Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma
    Batchelor, Tracy T.
    Mulholland, Paul
    Neyns, Bart
    Nabors, L. Burt
    Campone, Mario
    Wick, Antje
    Mason, Warren
    Mikkelsen, Tom
    Phuphanich, Surasak
    Ashby, Lynn S.
    DeGroot, John
    Gattamaneni, Rao
    Cher, Lawrence
    Rosenthal, Mark
    Payer, Franz
    Juergensmeier, Juliane M.
    Jain, Rakesh K.
    Sorensen, A. Gregory
    Xu, John
    Liu, Qi
    van den Bent, Martin
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (26) : 3212 - 3218
  • [3] A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma
    Brandes, Alba A.
    Carpentier, Antoine F.
    Kesari, Santosh
    Sepulveda-Sanchez, Juan M.
    Wheeler, Helen R.
    Chinot, Olivier
    Cher, Lawrence
    Steinbach, Joachim P.
    Capper, David
    Specenier, Pol
    Rodon, Jordi
    Cleverly, Ann
    Smith, Claire
    Gueorguieva, Ivelina
    Miles, Colin
    Guba, Susan C.
    Desaiah, Durisala
    Lahn, Michael M.
    Wick, Wolfgang
    [J]. NEURO-ONCOLOGY, 2016, 18 (08) : 1146 - 1156
  • [4] A phase II study of galunisertib monotherapy or galunisertib plus lomustine compared to lomustine monotherapy in recurrent glioblastoma
    Brandes, Alba Ariela
    Carpentier, Antoine F.
    Kesari, Santosh
    Sepulveda, Juan
    Wheeler, Helen
    Chinot, Olivier L.
    Cher, Lawrence
    Steinbach, Joachim Peter
    Specenier, Pol
    Cleverly, Ann
    Smith, Claire
    Gueorguieva, Ivelina
    Guba, Susan C.
    Desaiah, Durisala
    Lahn, Michael M. F.
    Wick, Wolfgang
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [5] Phase III Study of Enzastaurin Compared With Lomustine in the Treatment of Recurrent Intracranial Glioblastoma
    Wick, Wolfgang
    Puduvalli, Vinay K.
    Chamberlain, Marc C.
    van den Bent, Martin J.
    Carpentier, Antoine F.
    Cher, Lawrence M.
    Mason, Warren
    Weller, Michael
    Hong, Shengyan
    Musib, Luna
    Liepa, Astra M.
    Thornton, Donald E.
    Fine, Howard A.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (07) : 1168 - 1174
  • [6] Randomized phase II study of axitinib alone or combined with lomustine in patients with recurrent glioblastoma.
    Duerinck, Johnny
    Du Four, Stephanie
    Bouttens, Frank
    Verschaeve, Vincent
    Andre, Chantal
    Van Fraeyenhove, Frank
    Chaskis, Cristo
    D'Haene, Nicky
    Le Mercier, Marie
    Salmon, Isabelle
    Neyns, Bart
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [7] Randomized phase II trial comparing axitinib with the combination of axitinib and lomustine in patients with recurrent glioblastoma
    Duerinck, J.
    Du Four, S.
    Bouttens, F.
    Andre, C.
    Verschaeve, V.
    Van Fraeyenhove, F.
    Chaskis, C.
    D'Haene, N.
    Le Mercier, M.
    Rogiers, A.
    Michotte, A.
    Salmon, I.
    Neyns, B.
    [J]. JOURNAL OF NEURO-ONCOLOGY, 2018, 136 (01) : 115 - 125
  • [8] Randomized phase II trial comparing axitinib with the combination of axitinib and lomustine in patients with recurrent glioblastoma
    J. Duerinck
    S. Du Four
    F. Bouttens
    C. Andre
    V. Verschaeve
    F. Van Fraeyenhove
    C. Chaskis
    N. D’Haene
    M. Le Mercier
    A. Rogiers
    A. Michotte
    I. Salmon
    B. Neyns
    [J]. Journal of Neuro-Oncology, 2018, 136 : 115 - 125
  • [9] A PHASE I, OPEN LABEL, MULTICENTER STUDY TO ASSESS THE SAFETY AND TOLERABILITY OF CEDIRANIB (RECENTINTM) IN COMBINATION WITH LOMUSTINE CHEMOTHERAPY FOR PATIENTS WITH RECURRENT GLIOBLASTOMA
    Batchelor, T. T.
    de Bono, J. S.
    Wen, P. Y.
    Drappatz, J.
    Plotkin, S. R.
    Hochberg, F. H.
    Chi, A. S.
    Harris, D.
    Barriuso, J.
    Frentzas, S.
    Robertson, J.
    Xu, Q.
    Liu, Q.
    [J]. NEURO-ONCOLOGY, 2009, 11 (06) : 905 - 905
  • [10] Toxicity and efficacy of lomustine and bevacizumab in recurrent glioblastoma patients
    Jakobsen, J. N.
    Urup, T.
    Grunnet, K.
    Toft, A.
    Johansen, M. D.
    Poulsen, S. H.
    Christensen, I. J.
    Muhic, A.
    Poulsen, H. S.
    [J]. JOURNAL OF NEURO-ONCOLOGY, 2018, 137 (02) : 439 - 446