Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia

被引：33
|
作者：
Giovannetti, Elisa [2 ]
Ugrasena, Dewa G. [3 ]
Supriyadi, Eddy [4 ]
Vroling, Laura [2 ]
Azzarello, Antonino [2 ]
de lange, Desiree [1 ]
Peters, Godefridus J. [2 ]
Veerman, Anjo J. P. [1 ]
Cloos, Jacqueline [1 ]
机构：
[1] Vrije Univ Amsterdam Med Ctr, VU Inst Canc & Immunol, Dept Paediat Oncol Hematol, NL-1081 HV Amsterdam, Netherlands
[2] Vrije Univ Amsterdam Med Ctr, VU Inst Canc & Immunol, Dept Med Oncol, NL-1081 HV Amsterdam, Netherlands
[3] Airlangga Univ Surabaya, Dept Child Hlth, Surabaya, Indonesia
[4] Gadjah Mada Univ, Dept Paediat Hematooncol, Yogyakarta, Indonesia
来源：
LEUKEMIA RESEARCH | 2008年 / 32卷 / 01期
关键词：
acute lymphoblastoid leukernia; paediatric patients; methotrexate; MTHFR C677T; TSER; 2R/3R; Indonesia;
D O I：
10.1016/j.leukres.2007.02.011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Genetic variations in the polymorphic tandem repeat sequence of the enhancer region of the thymidylate synthase promoter(TSER), as we] I as in methylenetetrahydrofolate reduclase (MTHFR) C677T polymorphism, influence methotrexate sensitivity. We studied these polymorphisms in children with acute lymphoblastic leukaemia (ALL) and in subjects without malignancy in Indonesia and Holland. The frequencies of 77 and CT genotypes were two-fold higher in Dutch children. The TSER 3R/3R repeat was three-fold more frequent in the Indonesian children, while the 2R/2R repeat was only 1% compared to 21% in the Dutch children. No differences of these polymorphisms were found between ALL cells and normal blood cells, indicating an ethnic rather than leukemic origin. These results may have implications for treatment of Indonesian children with ALL. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：19 / 24
页数：6
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