Challenges and opportunities for the next generation of cardiovascular tissue engineering

被引:63
|
作者
Cho, Sangkyun [1 ,2 ]
Discher, Dennis E. [3 ,4 ]
Leong, Kam W. [5 ]
Vunjak-Novakovic, Gordana [5 ,6 ]
Wu, Joseph C. [1 ,2 ]
机构
[1] Stanford Cardiovasc Inst, Stanford, CA 94305 USA
[2] Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA
[3] Univ Penn, Mol & Cell Biophys Lab, Philadelphia, PA 19104 USA
[4] Univ Penn, Perelman Sch Med, Penn Muscle Inst, Philadelphia, PA 19104 USA
[5] Columbia Univ, Dept Biomed Engn, New York, NY USA
[6] Columbia Univ, Dept Med, New York, NY USA
基金
美国国家卫生研究院;
关键词
PLURIPOTENT STEM-CELLS; ON-A-CHIP; CARDIAC MICROTISSUES; CARDIOMYOCYTE MATURATION; EXTRACELLULAR-MATRIX; PLATFORM; DIFFERENTIATION; MODEL; RECONSTITUTION; CONTRACTILITY;
D O I
10.1038/s41592-022-01591-3
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
In this Perspective, technologies and challenges in the cardiac tissue engineering field are discussed and strategies to overcome these challenges are proposed. Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since the first engineered hearts were introduced over two decades ago, human induced pluripotent stem cell-based three-dimensional cardiac organoids and heart-on-a-chip systems have now become mainstays in basic cardiovascular research as valuable platforms for investigating fundamental human pathophysiology and development. However, major obstacles remain to be addressed before the field can truly advance toward commercial and clinical translation. Here we provide a snapshot of the state-of-the-art methods in cardiac tissue engineering, with a focus on in vitro models of the human heart. Looking ahead, we discuss major challenges and opportunities in the field and suggest strategies for enabling broad acceptance of engineered cardiac tissues as models of cardiac pathophysiology and testbeds for the development of therapies.
引用
收藏
页码:1064 / 1071
页数:8
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