A variant in the fibrillin-3 gene is associated with TGF-β and inhibin B levels in women with polycystic ovary syndrome

被引：50
|
作者：
Raja-Khan, Nazia [2 ]
Kunselman, Allen R. [3 ]
Demers, Laurence M. [2 ]
Ewens, Kathryn G. [4 ]
Spielman, Richard S. [4 ]
Legro, Richard S. [1 ]
机构：
[1] Penn State Univ, Coll Med, Dept Obstet & Gynecol, Hershey, PA 17033 USA
[2] Penn State Univ, Coll Med, Dept Med, Hershey, PA 17033 USA
[3] Penn State Univ, Coll Med, Dept Publ Hlth Sci, Hershey, PA 17033 USA
[4] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA
来源：
FERTILITY AND STERILITY | 2010年 / 94卷 / 07期
关键词：
Polycystic ovary syndrome; TGF-beta; inhibin; fibrillin; genetic association study; hyperandrogenism; insulin resistance; CHROMOSOME; 19P13.2; MARFANS-SYNDROME; ACTIVIN-A; FOLLISTATIN; HYPERANDROGENEMIA; SUSCEPTIBILITY; PHENOTYPE; IMPROVES; ARREST; GROWTH;
D O I：
10.1016/j.fertnstert.2010.05.047
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
In an attempt to evaluate the association between allele 8 (A8) of D19S884 in the fibrillin-3 gene and circulating transforming growth factor (TGF) beta and inhibin levels in women with polycystic ovary syndrome (PCOS), we studied 120 similarly aged women from families with PCOS and compared 40 women with PCOS who did not have A8 (A8- PCOS) with 40 women with PCOS who had A8 (A8+ PCOS) and 40 normally menstruating women who did not have either PCOS or A8 (A8- Non-PCOS). A8- PCOS is associated with higher levels of TGF-beta 1 compared with A8+ PCOS or A8- Non-PCOS, similar levels of TGF-beta 2 compared with A8+ PCOS but lower levels of TGF-beta 2 compared with A8- Non-PCOS, and lower levels of inhibin B and aldosterone compared with A8+ PCOS. (Fertil Steril (R) 2010;94:2916-9. (c) 2010 by American Society for Reproductive Medicine.)
引用
收藏
页码：2916 / 2919
页数：4
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