C-kit Expression in Oral Leukoplakia

被引：0

作者：

Tegginamani, Anand S. ^{[1
]}

Shivakumar, Vanishree H. ^{[1
]}

Ismail, Siti Mazlipah B. ^{[2
]}

Abraham, Mannil T. ^{[3
]}

Fernandes, Bennete A. ^{[1
]}

Zamzuri, Ahmad Termizi B. ^{[1
]}

机构：

[1] SEGi Univ, Fac Dent, Petaling Jaya, Selangor, Malaysia

[2] Univ Malaya, Fac Dent, Kuala Lumpur, Malaysia

[3] Sentosa Specialist Hosp, Dept Dent, Klang, Selangor, Malaysia

来源：

JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN | 2022年 / 32卷 / 02期

关键词：

CD; 117; Disease progression; Oral dysplasia; Oral leukoplakia; Risk prediction; CD117;

D O I：

10.29271/jcpsp.2022.02.256

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Oral leukoplakia is the most common potentially malignant oral disorder. Oral leukoplakia's malignant potential is independent of the histopathological grade, and the malignant transformation rate varies greatly from 3% to 50% even in the case of severe epithelial dysplasia. Ethnic & environmental variables may contribute to this variation. C-kit immunohistochemistry was performed on 15 oral leukoplakia (OL), two oral squamous cell carcinoma (OSCC), and two dentigerous cysts (DC). The objective of this study was to evaluate the c-kit expression in oral leukoplakia. The use of various immunohistochemical markers to differentiate between OLs with a high and low risk of malignant transformation has been investigated. Only four OL exhibited a faint cytoplasmic expression in basal cells. Whereas, OSCC and DC were devoid of c-kit expression. Thus, this may not be a unique marker for identifying OL at high-risk. Further research with larger sample size is required.

引用

页码：256 / 258

页数：3

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