In vivo photoacoustic tomography of myoglobin oxygen saturation

被引：25
|
作者：
Lin, Li [1 ]
Yao, Junjie [1 ]
Li, Lei [1 ]
Wang, Lihong V. [1 ]
机构：
[1] Washington Univ, Dept Biomed Engn, Opt Imaging Lab, St Louis, MO 63130 USA
来源：
JOURNAL OF BIOMEDICAL OPTICS | 2016年 / 21卷 / 06期
基金：
美国国家卫生研究院;
关键词：
myoglobin; oxygen saturation; calibration-free photoacoustic tomography; backbone muscle; MUSCLE; HEMOGLOBIN; LIGHT; SPECTROSCOPY; HEART;
D O I：
10.1117/1.JBO.21.6.061002
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Myoglobin is an essential oxygen-binding hemoprotein in skeletal and cardiac muscles that buffers intracellular oxygen (O-2) concentration in response to hypoxia or elevated muscle activities. We present a method that uses photoacoustic computed tomography to measure the distribution of myoglobin in tissue and the oxygen saturation of myoglobin (sO(2)-Mb). From photoacoustic measurements of mice in different oxygenation states, we performed calibration-free quantification of the sO(2)-Mb change in the backbone muscle in vivo. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
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页数：5
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