Oxytocin and social cognition in affective and psychotic disorders

被引：31

作者：

Mercedes Perez-Rodrigueza, M. ^{[1
,2
,3
,4
]}

Mahon, Katie ^{[1
]}

Russo, Manuela ^{[1
]}

Ungar, Allison K. ^{[1
]}

Burdick, Katherine E. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[2] James J Peters Vet Affairs Med Ctr, Mental Hlth Patient Care Ctr, Bronx, NY 10468 USA

[3] James J Peters Vet Affairs Med Ctr, Mental Illness Res Educ & Clin Ctr, Bronx, NY 10468 USA

[4] Univ Autonoma Madrid, CIBERSAM, Fdn Jimenez Diaz Hosp, E-28049 Madrid, Spain

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2015年 / 25卷 / 02期

关键词：

Oxytocin; Schizophrenia; Major depressive disorder; Bipolar disorder; Social cognition; INTERACTION TRAINING SCIT; FACIAL-AFFECT RECOGNITION; BORDERLINE PERSONALITY-DISORDER; ADJUNCTIVE INTRANASAL OXYTOCIN; VISUAL SCANNING BEHAVIOR; ATTRIBUTIONAL STYLE; BIPOLAR DISORDER; 1ST-EPISODE SCHIZOPHRENIA; IMPAIRED THEORY; MIND DEFICITS;

D O I：

10.1016/j.euroneuro.2014.07.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Impairments in social cognition are now recognized as core illness features in psychotic and affective disorders. Despite the significant disability caused by social cognitive abnormalities, treatments for this symptom dimension are lacking. Here, we describe the evidence demonstrating abnormalities in social cognition in schizophrenia, major depressive disorder, and bipolar disorder, as well as the neurobiology of social cognition including the role of oxytocin. We then review clinical trials of oxytocin administration in psychotic and affective disorders and the impact of this agent on social cognition. To date, several studies have demonstrated that oxytocin may improve social cognition in schizophrenia; too few studies have been conducted in affective disorders to determine the effect of oxytocin on social cognition in these disorders. Future work is needed to clarify which aspects of social cognition may be improved with oxytocin treatment in psychotic and affective disorders. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.

引用

页码：265 / 282

页数：18

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