RETRACTED: Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway (Retracted article. See April, 2017)

被引：30
|
作者：
Li, Jun [1 ]
Song, Zhangjun [2 ]
Wang, Yiyu [1 ]
Yin, Yue [1 ]
Liu, Ying [1 ]
Yuan, Rong [1 ]
Nan, Xing [1 ]
机构：
[1] Shaanxi Prov Tumor Hosp, Tumor Res Ctr, 309 YanTa West Rd, Xian 710061, Peoples R China
[2] Shaanxi Prov Tumor Hosp, Breast Surg Ctr, Xian 710061, Peoples R China
来源：
TUMOR BIOLOGY | 2016年 / 37卷 / 08期
关键词：
Sphingosine kinase 1; Sphingosine-1-phosphate; Triple-negative breast cancer; Chemotherapy; AKT; PI3K; SPHINGOSINE KINASE 1; THERAPEUTIC TARGET; COLON-CANCER; SURVIVAL; 1-PHOSPHATE; EXPRESSION; PROGNOSIS; APOPTOSIS;
D O I：
10.1007/s13277-016-4954-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sphingosine kinase 1 (SphK1) expression is elevated in various cancers and is associated with shorter survival times for patients. However, the molecular mechanism of SphK1 up-regulation in triple-negative breast cancer (TNBC) remains unclear. In this study, we assayed the expression level of SphK1 in TNBC tissues by qRT-PCR and immunohistochemistry. The level of S1P was quantified by ELISA in the serum of TNBC patients. Our results found that the levels of SphK1 and S1P were significantly increased in TNBC patients compared with normal control. Furthermore, knockdown of SphK1 with siRNA decreased TNBC cell proliferation and inhibited cell migration/invasion. These data suggest that SphK1 has an important role in TNBC and presents an attractive therapeutic target for the treatment for TNBC.
引用
收藏
页码：10587 / 10593
页数：7
相关论文
共 50 条
  • [1] RETRACTION: Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway (Retraction of Vol 37, Pg 10587, 2016)
    Stigbrand, Torgny
    TUMOR BIOLOGY, 2017,
  • [2] RETRACTED: SPHK1 inhibitor suppresses cell proliferation and invasion associated with the inhibition of NF-κB pathway in hepatocellular carcinoma (Retracted article. See April, 2017)
    Zhang, Zijie
    Yan, Zhenyu
    Yuan, Zheng
    Sun, Yanzhen
    He, Haifa
    Mai, Chunyang
    TUMOR BIOLOGY, 2015, 36 (03) : 1503 - 1509
  • [3] RETRACTED: Oxymatrine Inhibits the Proliferation and Invasion of Breast Cancer Cells via the PI3K Pathway (Retracted article. See vol. 14, pg. 2289, 2022)
    Guo, Lin
    Yang, Tengfei
    CANCER MANAGEMENT AND RESEARCH, 2019, 11 : 10499 - 10508
  • [4] RETRACTED: Deoxypodophyllotoxin inhibits cell viability and invasion by blocking the PI3K/Akt signaling pathway in human glioblastoma cells (Retracted article. See vol. 50, 2023)
    Wang, Wei
    Gao, Wei
    Zhang, Luyang
    Zhang, Dongyong
    Zhao, Zilong
    Bao, Yijun
    ONCOLOGY REPORTS, 2019, 41 (04) : 2453 - 2463
  • [5] RETRACTED: DDTC Suppresses Ovarian Cancer Development via the PI3K/AKT/mTOR Signaling Pathway (Retracted Article)
    Li, Meng
    Zhang, Wenqi
    Wang, Yihan
    Huang, Kai
    Sun, Tao
    Qiu, Zhicong
    Yang, Linqi
    Wu, Meng
    Zhang, Xiaolu
    Zhang, Wei
    DISEASE MARKERS, 2022, 2022
  • [6] RETRACTED: APRIL Induces Tumorigenesis and Metastasis of Colorectal Cancer Cells via Activation of the PI3K/Akt Pathway (Retracted Article)
    Wang, Guihua
    Wang, Feng
    Ding, Weifeng
    Wang, Jingchun
    Jing, Rongrong
    Li, Haiquan
    Wang, Xudong
    Wang, Yueguo
    Ju, Shaoqing
    Wang, Huimin
    PLOS ONE, 2013, 8 (01):
  • [7] Targeting PI3K/AKT pathway in triple-negative breast cancer
    Delaloge, Suzette
    DeForceville, Louise
    LANCET ONCOLOGY, 2017, 18 (10): : 1293 - 1294
  • [8] RETRACTED: BAP31 Promotes Proliferation, Invasion, and Metastasis of Liver Cancer Cells via Activating PI3K/AKT Pathway (Retracted Article)
    Sun, Minmin
    Liu, Xue
    Wei, Wanying
    Ge, Naijian
    Luo, Shuli
    Shen, Shuqun
    Ge, Ruiliang
    JOURNAL OF HEALTHCARE ENGINEERING, 2022, 2022
  • [9] RETRACTED: Effects of miR-214 on cervical cancer cell proliferation, apoptosis and invasion via modulating PI3K/AKT/mTOR signal pathway (Retracted Article)
    Wang, F.
    Tan, W-H.
    Liu, W.
    Jin, Y-X.
    Dong, D-D.
    Zhao, X-J.
    Liu, Q.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2018, 22 (07) : 1891 - 1898
  • [10] RETRACTED: Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells (Retracted article. See vol. 63, 2023)
    Tian, Feng
    Ding, Ding
    Li, Dandan
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2015, 46 (06) : 2355 - 2363
12345