Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide

被引：13
|
作者：
Usui, Kenji [1 ,2 ]
Okada, Arisa [1 ]
Kobayashi, Keita [1 ]
Sugimoto, Naoki [1 ,2 ]
机构：
[1] Konan Univ, FIRST Fac Frontiers Innovat Res Sci & Technol, Chuo Ku, Kobe, Hyogo 6500047, Japan
[2] Konan Univ, FIBER Frontier Inst Biomol Engn Res, Chuo Ku, Kobe, Hyogo 6500047, Japan
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 07期
关键词：
G-QUADRUPLEX DNA; C-MYC; PROMOTER; HYBRIDIZATION; CALPASTATIN; STABILITY; SEQUENCE; STRAND;
D O I：
10.1039/c4ob02535k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We constructed a regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an on-to-off switching functionality, depending on the protease activity. This study introduces the new concept of a simple and powerful system for regulating quadruplex-related important biological events.
引用
收藏
页码：2022 / 2025
页数：4
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