Expression of HER2/NEU in Different Grades of Urothelial Carcinoma of Urinary Bladder

Aim: To demonstrate HER2/neu expression in various grades of urothelial carcinoma of urinary bladder. Methodology: This descriptive study was done in four tertiary care hospitals of Lahore and Faisalabad during period of one year. HER2/neu expression was examined in specimens from 90 patients of urothelial carcinomas of urinary bladder by IHC (Immunohistochemistry).Frequency and percentage were calculated for histological grade of the tumor and expression of HER2/neu. Results: Mostly the patients were >66 years of age and male to female ratio was 5:1. +2 and +3 scores of HER2/neu expression were 20%(n=18) and 18.9%(n=17) respectively i.e. maximum in high grade cancer when comparing with low grade tumors i.e. +2 and +3 scores (8.9%,n=08 and 3.3%,03) respectively. Conclusion: There is positive association between grades of urothelial cancer & HER2/neu expression scores.