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- [1] Mechanisms of Efficacy of the FGFR1–3 Inhibitor AZD4547 in Pediatric Solid Tumor ModelsInvestigational New Drugs, 2020, 38 : 1677 - 1686Nikki Phanhthilath论文数: 0 引用数: 0 h-index: 0机构: University of California San Diego,Department of Pediatrics, Division of HematologySara Hakim论文数: 0 引用数: 0 h-index: 0机构: University of California San Diego,Department of Pediatrics, Division of HematologyCatherine Su论文数: 0 引用数: 0 h-index: 0机构: University of California San Diego,Department of Pediatrics, Division of HematologyAndrea Liu论文数: 0 引用数: 0 h-index: 0机构: University of California San Diego,Department of Pediatrics, Division of HematologyDivya Subramonian论文数: 0 引用数: 0 h-index: 0机构: University of California San Diego,Department of Pediatrics, Division of HematologyJacqueline Lesperance论文数: 0 引用数: 0 h-index: 0机构: University of California San Diego,Department of Pediatrics, Division of HematologyPeter E. Zage论文数: 0 引用数: 0 h-index: 0机构: University of California San Diego,Department of Pediatrics, Division of Hematology
- [2] Mechanisms of Efficacy of the FGFR1-3 Inhibitor AZD4547 in Pediatric Solid Tumor ModelsINVESTIGATIONAL NEW DRUGS, 2020, 38 (06) : 1677 - 1686Phanhthilath, Nikki论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USA Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USAHakim, Sara论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USA Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USASu, Catherine论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USA Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USALiu, Andrea论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USA Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USASubramonian, Divya论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USA Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USALesperance, Jacqueline论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USA Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USAZage, Peter E.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USA Rady Childrens Hosp, Peckham Ctr Canc & Blood Disorders, San Diego, CA 92123 USA Univ Calif San Diego, Div Hematol Oncol, Dept Pediat, 3855 Hlth Sci Dr,MC 0815, La Jolla, CA 92093 USA
- [3] The efficacy and mechanism of pan-FGFR inhibitor (AZD4547) combined with immunoagonists or immunosuppressants in FGFR-positive tumorsANNALS OF ONCOLOGY, 2024, 35 : S687 - S688Ma, Q.论文数: 0 引用数: 0 h-index: 0机构: West China Hosp Sichuan Univ, State Key Lab Biotherapy & Canc Ctr, Thorac Oncol Ward, Chengdu, Peoples R China West China Hosp Sichuan Univ, State Key Lab Biotherapy & Canc Ctr, Thorac Oncol Ward, Chengdu, Peoples R ChinaLiao, R.论文数: 0 引用数: 0 h-index: 0机构: Sichuan Univ, West China Hosp, Ctr Canc, Chengdu, Peoples R China West China Hosp Sichuan Univ, State Key Lab Biotherapy & Canc Ctr, Thorac Oncol Ward, Chengdu, Peoples R ChinaWang, Y.论文数: 0 引用数: 0 h-index: 0机构: West China Hosp, Ctr Canc, State Key Lab Biotherapy, Thorac Oncol Ward, Chengdu, Sichuan, Peoples R China West China Hosp Sichuan Univ, State Key Lab Biotherapy & Canc Ctr, Thorac Oncol Ward, Chengdu, Peoples R China
- [4] Evaluation of the pan-FGFR inhibitor AZD4547 with radiation in non-small cell lung cancerCANCER RESEARCH, 2019, 79 (13)Miller, Margot论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Madison, WI USA Univ Wisconsin, Madison, WI USAFisher, Michael论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Madison, WI USA Univ Wisconsin, Madison, WI USASenthilkumar, Gopika论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Madison, WI USA Univ Wisconsin, Madison, WI USAKaushik, Saakshi论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Madison, WI USA Univ Wisconsin, Madison, WI USAAble, Lindsey论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Madison, WI USA Univ Wisconsin, Madison, WI USABrennan, Sean论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Madison, WI USA Univ Wisconsin, Madison, WI USAIyer, Gopal论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Madison, WI USA Univ Wisconsin, Madison, WI USAKimple, Randall论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Madison, WI USA Univ Wisconsin, Madison, WI USABaschnagel, Andrew M.论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Madison, WI USA Univ Wisconsin, Madison, WI USA
- [5] Combining the pan-FGFR inhibitor AZD4547 with radiation in lung and head and neck squamous cell carcinomaCANCER RESEARCH, 2017, 77Baschnagel, Andrew M.论文数: 0 引用数: 0 h-index: 0Li, Chunrong论文数: 0 引用数: 0 h-index: 0Morgan, Alecia M.论文数: 0 引用数: 0 h-index: 0Brennan, Sean R.论文数: 0 引用数: 0 h-index: 0Russo, Kalley A.论文数: 0 引用数: 0 h-index: 0Harari, Paul M.论文数: 0 引用数: 0 h-index: 0
- [6] Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547CANCER RESEARCH, 2018, 78 (19) : 5668 - 5679Kas, Sjors M.论文数: 0 引用数: 0 h-index: 0机构: Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands Oncode Inst, Amsterdam, Netherlands Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlandsde Ruiter, Julian R.论文数: 0 引用数: 0 h-index: 0机构: Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands Oncode Inst, Amsterdam, Netherlands Netherlands Canc Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands Netherlands Canc Inst, Div Mol Pathol, Amsterdam, NetherlandsSchipper, Koen论文数: 0 引用数: 0 h-index: 0机构: Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands Oncode Inst, Amsterdam, Netherlands Netherlands Canc Inst, Div Mol Pathol, Amsterdam, NetherlandsSchut, Eva论文数: 0 引用数: 0 h-index: 0机构: Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands Oncode Inst, Amsterdam, Netherlands Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands论文数: 引用数: h-index:机构:Wientjens, Ellen论文数: 0 引用数: 0 h-index: 0机构: Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands Oncode Inst, Amsterdam, Netherlands Netherlands Canc Inst, Div Mol Pathol, Amsterdam, NetherlandsDrenth, Anne Paulien论文数: 0 引用数: 0 h-index: 0机构: Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands Oncode Inst, Amsterdam, Netherlands Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlandsde Korte-Grimmerink, Renske论文数: 0 引用数: 0 h-index: 0机构: Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands Oncode Inst, Amsterdam, Netherlands Netherlands Canc Inst, Div Mol Pathol, Amsterdam, NetherlandsMahakena, Sunny论文数: 0 引用数: 0 h-index: 0机构: Netherlands Canc Inst, Div Mol Oncol, Amsterdam, Netherlands Netherlands Canc Inst, Div Mol Pathol, Amsterdam, NetherlandsPhillips, Christopher论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, IMED Biotech Unit, Discovery Sci, Cambridge, England Netherlands Canc Inst, Div Mol Pathol, Amsterdam, NetherlandsSmith, Paul D.论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, IMED Biotech Unit, Biosci Oncol, Cambridge, England Netherlands Canc Inst, Div Mol Pathol, Amsterdam, NetherlandsKlarenbeek, Sjoerd论文数: 0 引用数: 0 h-index: 0机构: Netherlands Canc Inst, Expt Anim Pathol, Amsterdam, Netherlands Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlandsvan de Wetering, Koen论文数: 0 引用数: 0 h-index: 0机构: Netherlands Canc Inst, Div Mol Genet, Amsterdam, Netherlands Sidney Kimmel Med Coll, Dept Dermatol & Cutaneous Biol, Philadelphia, PA USA Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands论文数: 引用数: h-index:机构:Wessels, Lodewyk F. A.论文数: 0 引用数: 0 h-index: 0机构: Oncode Inst, Amsterdam, Netherlands Netherlands Canc Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands Delft Univ Technol, Dept EEMCS, Delft, Netherlands Netherlands Canc Inst, Div Mol Pathol, Amsterdam, NetherlandsJonkers, Jos论文数: 0 引用数: 0 h-index: 0机构: Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands Oncode Inst, Amsterdam, Netherlands Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands
- [7] High efficacy of BAY 1187982, an FGFR2-ADC, in overcoming drug resistance in a diffuse type gastric cancer patient-derived xenograft model with acquired resistance to pan-FGFR inhibitor AZD4547CANCER RESEARCH, 2016, 76Lau, Wen Min论文数: 0 引用数: 0 h-index: 0Teng, Eileen论文数: 0 引用数: 0 h-index: 0Huang, Kie Kyon论文数: 0 引用数: 0 h-index: 0Tan, Jin Wei论文数: 0 引用数: 0 h-index: 0Teh, Ming论文数: 0 引用数: 0 h-index: 0Yong, Wei Peng论文数: 0 引用数: 0 h-index: 0Sommer, Anette论文数: 0 引用数: 0 h-index: 0Schatz, Christoph A.论文数: 0 引用数: 0 h-index: 0Tan, Patrick论文数: 0 引用数: 0 h-index: 0Chan, Shing Leng论文数: 0 引用数: 0 h-index: 0So, Jimmy论文数: 0 引用数: 0 h-index: 0
- [8] The FGFR Family Inhibitor AZD4547 Exerts an Antitumor Effect in Ovarian Cancer CellsINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (19)Na, Yu Ran论文数: 0 引用数: 0 h-index: 0机构: Keimyung Univ, Sch Med, Dept Gynecol & Obstet, Daegu 42601, South Korea Keimyung Univ, Sch Med, Dept Gynecol & Obstet, Daegu 42601, South KoreaKim, Jin Young论文数: 0 引用数: 0 h-index: 0机构: Keimyung Univ Sch Med, Dept Internal Med, Daegu 42601, South Korea Keimyung Univ, Sch Med, Dept Gynecol & Obstet, Daegu 42601, South KoreaSong, Chang Ho论文数: 0 引用数: 0 h-index: 0机构: Keimyung Univ, Sch Med, Dept Gynecol & Obstet, Daegu 42601, South Korea Keimyung Univ, Sch Med, Dept Gynecol & Obstet, Daegu 42601, South KoreaKim, Mikyung论文数: 0 引用数: 0 h-index: 0机构: Keimyung Univ Sch Med, Dept Biochem, Daegu 42601, South Korea Keimyung Univ, Sch Med, Dept Gynecol & Obstet, Daegu 42601, South KoreaDo, Yen Thi论文数: 0 引用数: 0 h-index: 0机构: Keimyung Univ, Sch Med, Dept Gynecol & Obstet, Daegu 42601, South Korea Keimyung Univ, Sch Med, Dept Gynecol & Obstet, Daegu 42601, South KoreaVo, Tam Thuy Lu论文数: 0 引用数: 0 h-index: 0机构: Keimyung Univ Sch Med, Dept Biochem, Daegu 42601, South Korea Keimyung Univ, Sch Med, Dept Gynecol & Obstet, Daegu 42601, South KoreaChoi, Eunsom论文数: 0 引用数: 0 h-index: 0机构: Keimyung Univ, Sch Med, Dept Gynecol & Obstet, Daegu 42601, South Korea Keimyung Univ, Sch Med, Dept Gynecol & Obstet, Daegu 42601, South Korea论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:Shin, So-Jin论文数: 0 引用数: 0 h-index: 0机构: Keimyung Univ, Sch Med, Dept Gynecol & Obstet, Daegu 42601, South Korea Keimyung Univ, Sch Med, Dept Gynecol & Obstet, Daegu 42601, South Korea
- [9] Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1Acta Pharmacologica Sinica, 2023, 44 : 801 - 810Zuo-wei Wang论文数: 0 引用数: 0 h-index: 0机构: Hefei Institutes of Physical Science,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical TechnologyFeng-ming Zou论文数: 0 引用数: 0 h-index: 0机构: Hefei Institutes of Physical Science,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical TechnologyAo-li Wang论文数: 0 引用数: 0 h-index: 0机构: Hefei Institutes of Physical Science,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical TechnologyJing Yang论文数: 0 引用数: 0 h-index: 0机构: Hefei Institutes of Physical Science,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical TechnologyRui Jin论文数: 0 引用数: 0 h-index: 0机构: Hefei Institutes of Physical Science,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical TechnologyBei-lei Wang论文数: 0 引用数: 0 h-index: 0机构: Hefei Institutes of Physical Science,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical TechnologyLi-juan Shen论文数: 0 引用数: 0 h-index: 0机构: Hefei Institutes of Physical Science,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical TechnologyShuang Qi论文数: 0 引用数: 0 h-index: 0机构: Hefei Institutes of Physical Science,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical TechnologyJuan Liu论文数: 0 引用数: 0 h-index: 0机构: Hefei Institutes of Physical Science,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical TechnologyJing Liu论文数: 0 引用数: 0 h-index: 0机构: Hefei Institutes of Physical Science,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical TechnologyWen-chao Wang论文数: 0 引用数: 0 h-index: 0机构: Hefei Institutes of Physical Science,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical TechnologyQing-song Liu论文数: 0 引用数: 0 h-index: 0机构: Hefei Institutes of Physical Science,Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology
- [10] Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1ACTA PHARMACOLOGICA SINICA, 2023, 44 (04): : 801 - 810Wang, Zuo-wei论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China Univ Sci & Technol China, Hefei 230026, Peoples R China Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R ChinaZou, Feng-ming论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R ChinaWang, Ao-li论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R ChinaYang, Jing论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R ChinaJin, Rui论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R ChinaWang, Bei-lei论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R ChinaShen, Li-juan论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China Univ Sci & Technol China, Hefei 230026, Peoples R China Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R ChinaQi, Shuang论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R ChinaLiu, Juan论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R ChinaLiu, Jing论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R ChinaWang, Wen-chao论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R ChinaLiu, Qing-song论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China Univ Sci & Technol China, Hefei 230026, Peoples R China Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China Precis Med Res Lab Anhui Prov, Hefei 230088, Peoples R China Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China