Effect of hypothyroidism on TSH-receptor expression in rats and its possible role in the pathogenesis of thyroid-associated dermatopathy

被引：0

作者：

Bocheva, G. ^{[1
]}

Landzhov, B. ^{[1
]}

Bozhilova-Pastirova, A. ^{[1
]}

Boyadjieva, N. ^{[1
]}

Krushkov, I. ^{[1
]}

机构：

[1] Med Univ Sofia, Dept Pharmacol, Sofia 1431, Bulgaria

来源：

COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES | 2007年 / 60卷 / 07期

关键词：

TSH-R; hypothyroidism; skin; hypothalamo-pituitary axis; immunohistochemistry; rats;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The skin is a target for thyroid hormones and is an extrathyroid site for conversion of T4 into more active T3. Thyroid-associated dermatopathy is a common association in which skin exhibit typical abnormalities. Thyroid-stimulating hormone receptor (TSH-R) may play a role in these skin changes, serving as a target for autoantibodies. This study was designed to determine the effect of drug-induced hypothyroidism on the expression of TSH-R in hypothalamus, pituitary gland, and skin in rats, by immunohistochemistry. We found strong expression of the receptor in hypothalamus and dermal and hair follicle fibroblasts. These data suggest a possible role of TSH-R-stimulated pathways that could explain the mechanism of thyroid-associated dermatopathy.

引用

页码：805 / 808

页数：6

共 13 条

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