Two new tetracyclic triterpenoids from the endophytic fungus Hypoxylon sp. 6269

被引：12
|
作者：
Liang, Han-Qiao [1 ,2 ,3 ]
Zhang, Da-Wei [1 ,2 ,4 ]
Guo, Shun-Xing [1 ,2 ]
Yu, Jie [3 ]
机构：
[1] Chinese Acad Med Sci, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resource Utilizat Chinese, Beijing 100193, Peoples R China
[2] Peking Union Med Coll, Beijing 100193, Peoples R China
[3] Beijing City Univ, Biomed Sch, Beijing 100094, Peoples R China
[4] Jiangsu Univ Technol, Sch Elect & Informat Engn, Inst Bioinformat & Med Engn, Changzhou 213001, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2018年 / 20卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Endophytic fungus; tetracyclic triterpenoids; Hypoxylon sp; HIV-1; integrase; INTEGRASE; INHIBITION;
D O I：
10.1080/10286020.2018.1485662
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new tetracyclic triterpenoids, integracide E (1) and isointegracide E (2), as well as three known secondary metabolites (i.e. integracide A (3), 2-deoxyintegracide A (4) and 2-deoxyintegracide B (5)), were isolated from mycelium of the endophytic fungus Hypoxylon sp. 6269. Structures were determined by a combination of 1D and 2D NMR techniques and mass spectrometry. All of the compounds were tested for their anti-HIV-1 integrase activities. [GRAPHICS] .
引用
收藏
页码：951 / 956
页数：6
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