Red-shifted optogenetic excitation:: a tool for fast neural control derived from Volvox carteri

被引：392

作者：

Zhang, Feng ^{[2
,3
]}

Prigge, Matthias ^{[1
]}

Beyriere, Florent ^{[1
]}

Tsunoda, Satoshi P. ^{[1
]}

Mattis, Joanna ^{[2
,3
]}

Yizhar, Ofer ^{[2
,3
]}

Hegemann, Peter ^{[1
]}

Deisseroth, Karl ^{[2
,3
]}

机构：

[1] Humboldt Univ, Inst Biol Expt Biophys, D-10115 Berlin, Germany

[2] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Psychiat, Stanford, CA 94305 USA

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 06期

关键词：

D O I：

10.1038/nn.2120

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The introduction of two microbial opsin- based tools, channelrhodopsin-2 (ChR2) and halorhodopsin (NpHR), to neuroscience has generated interest in fast, multimodal, cell type-specific neural circuit control. Here we describe a cation-conducting channelrhodopsin (VChR1) from Volvox carteri that can drive spiking at 589 nm, with excitation maximum red-shifted similar to 70 nm compared with ChR2. These results demonstrate fast photostimulation with yellow light, thereby defining a functionally distinct third category of microbial rhodopsin proteins.

引用

页码：631 / 633

页数：3

共 16 条

[1] Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri
Feng Zhang
Matthias Prigge
Florent Beyrière
Satoshi P Tsunoda
Joanna Mattis
Ofer Yizhar
Peter Hegemann
Karl Deisseroth
Nature Neuroscience, 2008, 11 : 631 - 633
[2] Engineered red Opto-mGluR6 Opsins, a red-shifted optogenetic excitation tool, an in vitro study
Shamsnajafabadi, Hoda
Soheili, Zahra-Soheila
Sadeghi, Mehdi
Samiee, Shahram
Ghasemi, Pouria
Zibaii, Mohammad Ismail
Pourbadie, Hamid Gholami
Ahmadieh, Hamid
Pirmardan, Ehsan Ranaei
Salehi, Najmeh
Samiee, Dorsa
Kashanian, Ali
PLOS ONE, 2024, 19 (10):
[3] ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation
Lin, John Y.
Knutsen, Per Magne
Muller, Arnaud
Kleinfeld, David
Tsien, Roger Y.
NATURE NEUROSCIENCE, 2013, 16 (10) : 1499 - +
[4] ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation
John Y Lin
Per Magne Knutsen
Arnaud Muller
David Kleinfeld
Roger Y Tsien
Nature Neuroscience, 2013, 16 : 1499 - 1508
[5] Engineered red Opto-mGluR6 Opsins, a red-shifted optogenetic excitation tool, an in vitro study (vol 20, e0321044, 2024)
Shamsnajafabadi, Hoda
Soheili, Zahra-Soheila
Sadeghi, Mehdi
Samiee, Shahram
Ghasemi, Pouria
Zibaii, Mohammad Ismail
Gholami Pourbadie, Hamid
Ahmadieh, Hamid
Ranaei Pirmardan, Ehsan
Salehi, Najmeh
Samiee, Dorsa
Kashanian, Ali
PLOS ONE, 2025, 20 (03):
[6] Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship
Inagaki, Hidehiko K.
Jung, Yonil
Hoopfer, Eric D.
Wong, Allan M.
Mishra, Neeli
Lin, John Y.
Tsien, Roger Y.
Anderson, David J.
NATURE METHODS, 2014, 11 (03) : 325 - U311
[7] Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship
Inagaki H.K.
Jung Y.
Hoopfer E.D.
Wong A.M.
Mishra N.
Lin J.Y.
Tsien R.Y.
Anderson D.J.
Nature Methods, 2014, 11 (3) : 325 - 332
[8] Theoretical optimization of high-frequency optogenetic spiking of red-shifted very fast-Chrimson-expressing neurons
Gupta, Neha
Bansal, Himanshu
Roy, Sukhdev
NEUROPHOTONICS, 2019, 6 (02)
[9] Ultra-low power deep sustained optogenetic excitation of human ventricular cardiomyocytes with red-shifted opsins: a computational study
Pyari, Gur
Bansal, Himanshu
Roy, Sukhdev
JOURNAL OF PHYSIOLOGY-LONDON, 2022, 600 (21): : 4653 - 4676
[10] Imaging of Red-Shifted Light From Bioluminescent Tumors Using Fluorescence by Unbound Excitation From Luminescence
Sonego, Fabiane
Bouccara, Sophie
Pons, Thomas
Lequeux, Nicolas
Danckaert, Anne
Tinevez, Jean-Yves
Alam, Israt S.
Shorte, Spencer L.
Tournebize, Regis
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2019, 7 (APR)

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