Comparative use of solvent-free KF-Al2O3 and K2CO3 in acetone in the synthesis of quinoxaline 1,4-dioxide derivatives designed as antimalarial drug candidates

被引：14

作者：

Lima, LM

Zarranz, B

Marin, A

Solano, B

Vicente, E

Silanes, SP

Aldana, I ^{[1
]}

Monge, A

机构：

[1] Univ Navarra, Unidad Invest & Desarrollo Medicamentos, Ctr Invest Farmacobiol Aplicada, E-31080 Pamplona, Spain

[2] Univ Fed Rio de Janeiro, LASSBio, Fac Farm, BR-21944970 Rio De Janeiro, Brazil

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2005年 / 42卷 / 07期

关键词：

D O I：

10.1002/jhet.5570420718

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper we describe two new basic conditions for the synthesis of quinoxaline 1,4-dioxide derivatives in moderate to good yields. These conditions, exemplified by the use of K2CO3 in acetone or KF/Al2O3 in the absence of an organic solvent, were reproducible and applicable to the synthesis of 2-(carboethoxy)-3-phenylquinoxaline 1,4-dioxide derivatives substituted in position 4 with electron-donating or electron-withdrawing groups.

引用

页码：1381 / 1385

页数：5

共 44 条

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