Total Synthesis of Two Pyrrole Spiroketal Alkaloids: Pollenopyrroside A and Capparisine B

被引：12
|
作者：
Cao, Zhi [1 ]
Li, Yueqing [1 ]
Wang, Shisheng [1 ]
Guo, Xiuhan [1 ]
Wang, Liu [1 ]
Zhao, Weijie [1 ]
机构：
[1] Dalian Univ Technol, Sch Pharmaceut Sci & Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China
来源：
SYNLETT | 2015年 / 26卷 / 07期
关键词：
alkaloids; spiroketals; natural products; total synthesis; microwave-assisted reaction; STEREOSELECTIVE-SYNTHESIS; PROTECTING GROUPS; CARBOHYDRATE; ACORTATARINS; DEPROTECTION;
D O I：
10.1055/s-0034-1380172
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pollenopyrroside A and capparisine B, two diastereoisomers of pyrrole spiroketal alkaloids isolated from Brassica campestris pollen and Capparis spinosa, were synthesized by an improved microwave-assisted bishydroxymethylation of pyrrole and acid-catalyzed spirocyclization as key steps with total yields of 2.7 and 8.8%, respectively.
引用
收藏
页码：921 / 926
页数：6
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