Enzymatic degradation of poly(ε-caprolactone) fibers in vitro

Poly(epsilon -caprolactone) (PCL) fibers were enzymatic degraded by a hydrolase in vitro. The extent of degradation of PCL fibers was examined by weight loss, mechanical properties loss such as tensile strength and ultimate elongation decrease, and visual observation by scanning electron microscopy. The in vitro degradation of PCL fibers was carried out using Lipase F-AP as a hydrolase. A kinetic study on the weight loss of PCL fiber accompanying the enzymatic degradation suggested degradation of PCL fibers gradually from the surface of the fibers into their core. Scanning electron microscopy supported surface, not bulk degradation. The rate of degradation was found to depend on draw ratio and crystallinity of the PCL fibers. Strength loss of PCL fibers in the course of degradation took place faster than weight loss of PCL fibers.