Age estimation in dental pulp DNA based on human telomere shortening

被引：50
|
作者：
Takasaki, T
Tsuji, A
Ikeda, N [1 ]
Ohishi, M
机构：
[1] Kyushu Univ, Grad Sch Med Sci, Dept Forens Pathol & Sci, Fukuoka 8128582, Japan
[2] Kyushu Univ, Fac Dent Sci, Div Maxillofacial Diagnost & Surg Sci, Fukuoka 8128582, Japan
来源：
INTERNATIONAL JOURNAL OF LEGAL MEDICINE | 2003年 / 117卷 / 04期
关键词：
age estimation; telomere shortening; dental pulp DNA; forensic odontology;
D O I：
10.1007/s00414-003-0376-5
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
Age estimation based on evidence found in teeth has received considerable attention within the field of forensic science. We determined the terminal restriction fragment (TRF) length, as telomere length, to estimate age. Using dental pulp DNA we found the average TRF length showed a tendency to shortening with aging. Our findings show that telomere shortening, based on dental pulp DNA is a new and useful approach to estimate age of the subject at the time of death.
引用
收藏
页码：232 / 234
页数：3
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