Novel Protein Therapeutics Created Using the Elastin-Like Polypeptide Platform

被引：10
|
作者：
Bidwell, Gene L., III [1 ,2 ]
机构：
[1] Univ Mississippi, Med Ctr, Dept Neurol Cell & Mol Biol, Jackson, MS 39216 USA
[2] Univ Mississippi, Med Ctr, Dept Pharmacol, Jackson, MS 39216 USA
来源：
PHYSIOLOGY | 2021年 / 36卷 / 06期
基金：
美国国家卫生研究院;
关键词：
controlled release; depot; drug delivery; elastin-like polypeptide; nanoparticle; NF-KAPPA-B; THERMALLY RESPONSIVE BIOPOLYMER; INTENSITY FOCUSED ULTRASOUND; CELL-PENETRATING PEPTIDES; NOTCH INHIBITORY PEPTIDE; ACUTE KIDNEY INJURY; DOXORUBICIN CONJUGATE; TUMOR-GROWTH; SUSTAINED-RELEASE; TYROSINE KINASE-1;
D O I：
10.1152/physiol.00026.2021
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Elastin-like polypeptides (ELPs) are bioengineered proteins that have a unique physical property, a thermally triggered inverse phase transition, that can be exploited for drug delivery. ELP-fusion proteins can be used as soluble biologics, thermally targeted drug carriers, self-assembling nanoparticles, and slow-release drug depots. Because of their unique physical characteristics and versatility for delivery of nearly any type of therapeutic, ELP-based drug delivery systems represent a promising platform for biologics development.
引用
收藏
页码：367 / 381
页数：15
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