Facile palladium-mediated conversion of ethanethiol esters to aldehydes and ketones

被引：0

作者：

Tokuyama, H ^{[1
]}

Yokoshima, S ^{[1
]}

Yamashita, T ^{[1
]}

Lin, SC ^{[1
]}

Li, LP ^{[1
]}

Fukuyama, T ^{[1
]}

机构：

[1] Univ Tokyo, Japan Sci & Technol Corp, CREST, Grad Sch Pharmaceut Sci,Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 1998年 / 9卷 / 04期

关键词：

thiol ester; aldehyde; ketone; trietyl silane; organozinc reagent; palladium-catalyst;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Treatment of ethanethiol esters with triethylsilane and palladium on carbon at ambient temperature furnished aldehydes. In addition, a variety of ketones have been prepared by a palladium-catalyzed reaction of ethanethiol esters with organozinc reagents. Various functional groups, including esters, ketones, aromatic halides and aldehydea, tolerate both transformation reactions. These novel reactions can also be applied to the synthesis of alpha-amino aldehyde and alpha-amino ketone derivatives using the corresponding L-alpha-amino thiol esters without causing racemization.

引用

页码：381 / 387

页数：7

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